Review
doi: 10.1016/j.intimp.2007.06.012.
Epub 2007 Jul 19.
Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide
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- PMID: 18182246
- DOI: 10.1016/j.intimp.2007.06.012
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Review
Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide
Int Immunopharmacol.
2008 Feb.
Abstract
Angiotensin II (Ang II) plays important roles in the regulation of cardiovascular functions and diseases mainly via the type 1 (AT1) receptor. In contrast, recent studies have shown that the actions of Ang II via the type 2 (AT2) receptor are counter-regulatory to those mediated via the AT1 receptor. Using an animal model of hypertension, we have demonstrated that Ang II produces a vasodilator effect through the AT2 receptor via the bradykinin (BK)-dependent activation of endothelial nitric oxide (NO) synthase. In this review, we focus on the role of BK and NO in AT2-receptor-mediated vasodilation.
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