Programmed cell death (apoptosis): its virological and immunological connections (a review)
- PMID: 1817429
Programmed cell death (apoptosis): its virological and immunological connections (a review)
Abstract
Programmed cell death is a physiological, energy-consuming mechanism leading to suicide of the cell. Cell death is accomplished by the activation of endonucleases that fragment the cell's nuclear DNA. Some tumour cells remain susceptible to programmed death. These are hormone- and growth factor-dependent tumour cells. Hormone or growth factor deprivation induces signals leading to apoptosis. Other tumours gain strong resistance to apoptosis. One of the normal functions of the bcl-2 gene is to provide longevity to memory B cells. When this gene becomes translocated in follicular B cell lymphomas, it renders lymphoma cells resistant to apoptosis. Latent membrane protein encoded by an EBV gene, either by itself or by amplifying bcl-2, enables tumour cells (nasopharyngeal carcinoma; Reed-Sternberg cell of Hodgkin's disease) to resist apoptotic death. Loss of antioncogene p53 provides for resistance against programmed cell death. Breakdown of resistance to apoptosis in tumour cells can be achieved by oncolytic viruses; generation of lymphotoxin and tumour necrosis factor; monoclonal antibodies; transfection with plasmid vectors carrying p53; gamma irradiation; and certain chemotherapeutic agents.
Similar articles
-
Physician Education: Apoptosis.Oncologist. 1996;1(6):399-401. Oncologist. 1996. PMID: 10388021
-
The role of apoptosis in normal ontogenesis and solid human neoplasms.In Vivo. 2000 Nov-Dec;14(6):789-803. In Vivo. 2000. PMID: 11204498
-
Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells.Anticancer Res. 1990 Sep-Oct;10(5A):1153-9. Anticancer Res. 1990. PMID: 2241096 Review.
-
Cytotoxic protein expression in non-Hodgkin's lymphomas and Hodgkin's disease.Anticancer Res. 1999 Mar-Apr;19(2A):1209-16. Anticancer Res. 1999. PMID: 10368677
-
Active cell death (apoptosis) and cellular proliferation as indicators of exposure to carcinogens.IARC Sci Publ. 1999;(146):273-85. IARC Sci Publ. 1999. PMID: 10353391 Review.
Cited by
-
Comments on cultured human sarcoma cells.Sarcoma. 2003;7(2):75-7. doi: 10.1080/13577140310001607301. Sarcoma. 2003. PMID: 18521372 Free PMC article.
-
Viral interleukin 10 is critical for the induction of B cell growth transformation by Epstein-Barr virus.J Exp Med. 1993 Aug 1;178(2):439-47. doi: 10.1084/jem.178.2.439. J Exp Med. 1993. PMID: 8393476 Free PMC article.
-
Preliminary investigation demonstrating the GHITM gene probably involved in apoptosis and growth of the golden apple snail (Pomacea canaliculata).BMC Genomics. 2020 Jan 6;21(1):19. doi: 10.1186/s12864-019-6434-2. BMC Genomics. 2020. PMID: 31906861 Free PMC article.
-
Apoptosis and pro-inflammatory cytokine response of mast cells induced by influenza A viruses.PLoS One. 2014 Jun 12;9(6):e100109. doi: 10.1371/journal.pone.0100109. eCollection 2014. PLoS One. 2014. PMID: 24923273 Free PMC article.
-
Interactions of Opioids and HIV Infection in the Pathogenesis of Chronic Pain.Front Microbiol. 2016 Feb 10;7:103. doi: 10.3389/fmicb.2016.00103. eCollection 2016. Front Microbiol. 2016. PMID: 26903982 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials
Miscellaneous