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Review
. 2007 Dec;4(6):407-18.

The interferon signaling network and transcription factor C/EBP-beta

Hui Li  1 , Padmaja Gade, Weihua Xiao, Dhan V Kalvakolanu
Affiliations
Review

The interferon signaling network and transcription factor C/EBP-beta

Hui Li et al. Cell Mol Immunol. 2007 Dec.

Abstract

Cytokines like interferons (IFNs) play a central role in regulating innate and specific immunities against the pathogens and neoplastic cells. A number of signaling pathways are induced in response to IFN in various cells. One classic mechanism employed by IFNs is the JAK-STAT signaling pathway for inducing cellular responses. Here we describe the non-STAT pathways that participate in IFN-induced responses. In particular, we will focus on the role played by transcription factor C/EBP-beta in mediating these responses.

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Figures

Figure 1
Figure 1. IFN-induced JAK-STAT signaling pathways
Figure 2
Figure 2. Molecular organization of the C/EBP-β protein
The ERK-phosphorylation site within the RD2 is shown.
Figure 3
Figure 3. A simplified view of the mitogen-activated protein kinase (MAPK) pathways
Three of the best studied modules, the ERK, JNK and p38 pathways are indicated. Each of them targets several cellular proteins including some transcription factors.
Figure 4
Figure 4. The mixed lineage kinases
Panel A shows the structure of MLK3. Panel B shows the groups of MLK family.
Figure 5
Figure 5. The IFN-γ-induced MAPK-signaling pathways regulate C/EBP-β
See this image and copyright information in PMC

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