Comment
doi: 10.1038/ncb1207-1341.
Leading the charge
- PMID: 18059355
- DOI: 10.1038/ncb1207-1341
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Comment
Leading the charge
Nat Cell Biol.
2007 Dec.
Abstract
Collective cell invasion into the extracellular matrix (ECM) has been observed in malignant tumours and in tissue morphogenesis. To achieve this, leading cells trigger both proteolytic and structural modifications of the ECM to create channels that precede progressively widening chains of following cells.
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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.Nat Cell Biol. 2007 Dec;9(12):1392-400. doi: 10.1038/ncb1658. Epub 2007 Nov 25. Nat Cell Biol. 2007. PMID: 18037882
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