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. 2008 May;38(5):465-73.
doi: 10.1111/j.1872-034X.2007.00299.x. Epub 2007 Nov 27.

Patterns of hepatocellular carcinoma incidence in Egypt from a population-based cancer registry

Elizabeth M Lehman  1 , Amr S Soliman, Kadry Ismail, Ahmed Hablas, Ibrahim A Seifeldin, Mohamed Ramadan, Hesham El-Hamzawy, Christiana S Shoushtari, Mark L Wilson
Affiliations

Patterns of hepatocellular carcinoma incidence in Egypt from a population-based cancer registry

Elizabeth M Lehman et al. Hepatol Res. 2008 May.

Abstract

Aim: Hepatocellular carcinoma (HCC) is increasing worldwide, and is frequently attributed to rising rates of hepatitis C virus infection and interactions between viral and environmental risk factors. Because of Egypt's unique risk factor profile, we analyzed data from the Gharbiah Population-Based Cancer Registry for the period 1999-2003 to characterize demographic and geographic patterns of cases in this province.

Methods: We calculated age- and sex-specific and age- and sex-standardized HCC incidence rates for the eight districts in Gharbiah. We also compared rates from Gharbiah with the USA (US Surveillance Epidemiology and End RESULTS [SEER] database).

Results: The analysis revealed a higher incidence in males than in females, significant geographic variations among districts, and a higher incidence in Gharbiah than that reported by SEER.

Conclusion: The findings of this study document the heterogeneous distribution of HCC at regional and international levels. This population-based registry offers the opportunity for careful representative studies of various etiologies, particularly infectious and/or environmental factors that may contribute to risk.

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Figures

Figure 1
Figure 1
Northern Egypt (Nile Delta), Gharbiah Province, and its eight districts. (Map: http://www.meccegypt.org).
Figure 2
Figure 2
Mean age-adjusted incidence rates for hepatocellular carcinoma in the eight districts of Gharbiah (1999–2003), standardized to the world million (Parkin et al. 1997). (Map: http://www.meccegypt.org).
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