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Review
. 2008;25(1):1-8.
doi: 10.1159/000111082. Epub 2007 Nov 15.

Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part II

Pauline Aalten  1 , Frans R J Verhey, Marina Boziki, Andrea Brugnolo, Roger Bullock, Eleanor Jane Byrne, Vincent Camus, Miriam Caputo, Debby Collins, Peter Paul De Deyn, Kazi Elina, Giovanni Frisoni, Clive Holmes, Catherine Hurt, Anna Marriott, Patrizia Mecocci, Flavio Nobili, Pierre Jean Ousset, Emma Reynish, Eric Salmon, Magda Tsolaki, Bruno Vellas, Philippe H Robert
Affiliations
Free article
Review

Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part II

Pauline Aalten et al. Dement Geriatr Cogn Disord. 2008.
Free article

Abstract

Background/aims: The aim of this study was to determine the consistency of neuropsychiatric subsyndromes of the Neuropsychiatric Inventory across several clinical and demographic subgroups (e.g. dementia subtypes, dementia severity, medication use, age and gender) in a large sample of outpatients with dementia.

Methods: Cross-sectional data of 2,808 patients with dementia from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Subanalyses were performed for dementia subtypes, dementia severity, medication use, age and gender.

Results: The results showed the relatively consistent presence of the 4 neuropsychiatric subsyndromes 'hyperactivity', 'psychosis', 'affective symptoms' and 'apathy' across the subanalyses. The factor structure was not dependent on dementia subtypes, age and gender but was dependent on dementia severity and cholinesterase use. The factors hyperactivity and affective symptoms were present in all subanalyses, but the presence of the factors apathy and psychosis was dependent on use of cholinesterase inhibitors and dementia severity, respectively.

Conclusion: The present study provided evidence of the relative consistency of neuropsychiatric subsyndromes across dementia subtypes, age and gender, thereby stressing the importance of thinking about neuropsychiatric subsyndromes instead of separate symptoms. However, the subsyndromes apathy and psychosis were dependent on use of cholinesterase inhibitors and dementia severity.

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