MicroRNAs in carcinogenesis
- PMID: 18000378
- DOI: 10.1159/000108308
MicroRNAs in carcinogenesis
Abstract
MicroRNAs are an abundant class of noncoding RNAs, typically 20-23 nucleotides in length that are often evolutionarily conserved in metazoans and expressed in a cell and tissue specific manner. MicroRNAs exert their gene regulatory activity primarily by imperfectly base pairing to the 3' UTR of their target mRNAs, leading to mRNA degradation or translational inhibition. In cancer, microRNAs are often dysregulated with their expression patterns being correlated with clinically relevant tumor characteristics. Recently, microRNAs were shown to be directly involved in cancer initiation and progression. This review focuses primarily on emerging developments in the microRNA field that impact our understanding of how these molecules contribute to carcinogenesis.
Copyright (c) 2007 S. Karger AG, Basel.
Similar articles
-
The role of microRNAs in cancer: no small matter.Eur J Cancer. 2007 Jul;43(10):1529-44. doi: 10.1016/j.ejca.2007.04.002. Epub 2007 May 24. Eur J Cancer. 2007. PMID: 17531469 Review.
-
Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis.Mutat Res. 2011 Jun 17;722(2):94-105. doi: 10.1016/j.mrgentox.2010.05.006. Epub 2010 May 21. Mutat Res. 2011. PMID: 20472093 Review.
-
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?Nat Rev Genet. 2008 Feb;9(2):102-14. doi: 10.1038/nrg2290. Nat Rev Genet. 2008. PMID: 18197166 Review.
-
MicroRNAs and their emerging roles in immunology.Ann N Y Acad Sci. 2008 Nov;1143:226-39. doi: 10.1196/annals.1443.009. Ann N Y Acad Sci. 2008. PMID: 19076353 Review.
-
Evidence for dietary regulation of microRNA expression in cancer cells.Nutr Rev. 2008 Aug;66(8):477-82. doi: 10.1111/j.1753-4887.2008.00080.x. Nutr Rev. 2008. PMID: 18667010 Review.
Cited by
-
Overexpression of miR-664 is associated with enhanced osteosarcoma cell migration and invasion ability via targeting SOX7.Clin Exp Med. 2017 Feb;17(1):51-58. doi: 10.1007/s10238-015-0398-6. Epub 2015 Oct 29. Clin Exp Med. 2017. PMID: 26515813
-
At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1.PLoS One. 2009;4(2):e4352. doi: 10.1371/journal.pone.0004352. Epub 2009 Feb 5. PLoS One. 2009. PMID: 19194500 Free PMC article.
-
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.Nat Struct Mol Biol. 2009 Oct;16(10):1021-5. doi: 10.1038/nsmb.1676. Epub 2009 Aug 27. Nat Struct Mol Biol. 2009. PMID: 19713958 Free PMC article.
-
MiRNA-615-5p functions as a tumor suppressor in pancreatic ductal adenocarcinoma by targeting AKT2.PLoS One. 2015 Apr 9;10(4):e0119783. doi: 10.1371/journal.pone.0119783. eCollection 2015. PLoS One. 2015. PMID: 25856297 Free PMC article.
-
A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment.Sci Rep. 2016 Feb 22;6:21565. doi: 10.1038/srep21565. Sci Rep. 2016. PMID: 26898246 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
