Comment
doi: 10.1016/j.cell.2007.10.023.
alphaPlGF: a new kid on the antiangiogenesis block
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- PMID: 17981110
- DOI: 10.1016/j.cell.2007.10.023
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alphaPlGF: a new kid on the antiangiogenesis block
Cell.
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Abstract
An agent that blocks tumor angiogenesis, growth, and metastasis without affecting normal tissues -- whether used alone or in combination with currently approved drugs -- would change the way we treat cancer. In this issue, Fischer et al. (2007) offer compelling evidence that a monoclonal antibody against placental growth factor (PlGF), a member of the VEGF family, has such potential in mice.
Comment on
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Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.Cell. 2007 Nov 2;131(3):463-75. doi: 10.1016/j.cell.2007.08.038. Cell. 2007. PMID: 17981115
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