Reversal of fortune: Rad5 to the rescue
- PMID: 17964257
- DOI: 10.1016/j.molcel.2007.10.001
Reversal of fortune: Rad5 to the rescue
Abstract
In a recent issue of Molecular Cell, Blastyák et al. (2007) show that the yeast Rad5 protein can promote error-free template switching and replication past a DNA lesion via a novel DNA unwinding reaction that also pairs nascent and parental strands.
Comment on
-
Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression.Mol Cell. 2007 Oct 12;28(1):167-75. doi: 10.1016/j.molcel.2007.07.030. Mol Cell. 2007. PMID: 17936713 Free PMC article.
Similar articles
-
Mms2-Ubc13-dependent and -independent roles of Rad5 ubiquitin ligase in postreplication repair and translesion DNA synthesis in Saccharomyces cerevisiae.Mol Cell Biol. 2006 Oct;26(20):7783-90. doi: 10.1128/MCB.01260-06. Epub 2006 Aug 14. Mol Cell Biol. 2006. PMID: 16908531 Free PMC article.
-
Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression.Mol Cell. 2007 Oct 12;28(1):167-75. doi: 10.1016/j.molcel.2007.07.030. Mol Cell. 2007. PMID: 17936713 Free PMC article.
-
A role for yeast and human translesion synthesis DNA polymerases in promoting replication through 3-methyl adenine.Mol Cell Biol. 2007 Oct;27(20):7198-205. doi: 10.1128/MCB.01079-07. Epub 2007 Aug 13. Mol Cell Biol. 2007. PMID: 17698580 Free PMC article.
-
The RAD6 pathway: control of DNA damage bypass and mutagenesis by ubiquitin and SUMO.Chembiochem. 2005 Oct;6(10):1735-43. doi: 10.1002/cbic.200500139. Chembiochem. 2005. PMID: 16142820 Review. No abstract available.
-
Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance.DNA Repair (Amst). 2010 Mar 2;9(3):257-67. doi: 10.1016/j.dnarep.2009.12.013. Epub 2010 Jan 21. DNA Repair (Amst). 2010. PMID: 20096653 Review.
Cited by
-
Large-scale expansions of Friedreich's ataxia GAA repeats in yeast.Mol Cell. 2009 Jul 10;35(1):82-92. doi: 10.1016/j.molcel.2009.06.017. Mol Cell. 2009. PMID: 19595718 Free PMC article.
-
Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1.Genetics. 2008 Jul;179(3):1197-210. doi: 10.1534/genetics.108.089003. Epub 2008 Jun 18. Genetics. 2008. PMID: 18562671 Free PMC article.
-
Expansion of Interstitial Telomeric Sequences in Yeast.Cell Rep. 2015 Nov 24;13(8):1545-51. doi: 10.1016/j.celrep.2015.10.023. Epub 2015 Nov 12. Cell Rep. 2015. PMID: 26586439 Free PMC article.
-
Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.Genetics. 2009 Jul;182(3):671-84. doi: 10.1534/genetics.109.102939. Epub 2009 Apr 20. Genetics. 2009. PMID: 19380905 Free PMC article.
-
Coordinated protein and DNA remodeling by human HLTF on stalled replication fork.Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14073-8. doi: 10.1073/pnas.1101951108. Epub 2011 Jul 27. Proc Natl Acad Sci U S A. 2011. PMID: 21795603 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous