doi: 10.1073/pnas.0708636104.
Epub 2007 Oct 24.
Rites of passage through puberty: a complex genetic ensemble
Affiliations
- PMID: 17959785
- PMCID: PMC2077239
- DOI: 10.1073/pnas.0708636104
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Rites of passage through puberty: a complex genetic ensemble
Proc Natl Acad Sci U S A.
.
No abstract available
Conflict of interest statement
The author declares no conflict of interest.
Figures
Genetic causes of hypogonadotropic hypogonadism. The hypothalamic–pituitary–gonadal (HPG) axis is depicted in Right. Hypothalamic gonadotropin-releasing hormone (GnRH) pulses stimulate pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) pulses that act on the gonads to stimulate gametogenesis and sex steroid, which feed back to regulate the hypothalamus and pituitary. Genes associated with hypogonadotropic hypogonadism are listed in Left below the steps they regulate. KAL1, Kallmann syndrome gene 1 (encodes anosmin 1); FGFR1, fibroblast growth factor receptor 1; NELF, nasal embryonic luteinizing hormone releasing hormone factor; PROK2, prokineticin 2; PROKR2, prokineticin receptor 2; GPR54, G protein receptor 54; LEP, leptin; LEPR, leptin receptor; SF1, steroidogenic factor 1 (also FTZF1 or NR5A1); DAX1, dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on X chromosome 1 (also, NROB1); GNRHR, GnRH receptor; LHB, LH-β; FSHB, FSH-β.
Comment on
- Proc Natl Acad Sci U S A. 104:17447.
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