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. 2007 Oct 19;318(5849):450-3.
doi: 10.1126/science.1145718.

Permuted tRNA genes expressed via a circular RNA intermediate in Cyanidioschyzon merolae

Akiko Soma  1 , Akinori Onodera, Junichi Sugahara, Akio Kanai, Nozomu Yachie, Masaru Tomita, Fujio Kawamura, Yasuhiko Sekine
Affiliations

Permuted tRNA genes expressed via a circular RNA intermediate in Cyanidioschyzon merolae

Akiko Soma et al. Science. .

Erratum in

  • Science. 2007 Dec 21;318(5858):1866

Abstract

A computational analysis of the nuclear genome of a red alga, Cyanidioschyzon merolae, identified 11 transfer RNA (tRNA) genes in which the 3' half of the tRNA lies upstream of the 5' half in the genome. We verified that these genes are expressed and produce mature tRNAs that are aminoacylated. Analysis of tRNA-processing intermediates for these genes indicates an unusual processing pathway in which the termini of the tRNA precursor are ligated, resulting in formation of a characteristic circular RNA intermediate that is then processed at the acceptor stem to generate the correct termini.

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Comment in

  • Genetics. Why genomes in pieces?
    Landweber LF. Landweber LF. Science. 2007 Oct 19;318(5849):405-7. doi: 10.1126/science.1150280. Science. 2007. PMID: 17947572 No abstract available.

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