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Review
. 2007 Jun;36(2):131-41.
doi: 10.1007/s12033-007-0020-6.

Exploiting dendritic cells for active immunotherapy of cancer and chronic infections

David W O'Neill  1 , Nina Bhardwaj
Affiliations
Review

Exploiting dendritic cells for active immunotherapy of cancer and chronic infections

David W O'Neill et al. Mol Biotechnol. 2007 Jun.

Abstract

Dendritic cells (DCs) are important antigen-presenting cells (APCs) that can prime naive T cells and control adaptive immune responses with respect to magnitude, memory and self-tolerance. Understanding the biology of these cells is central to the development of new generation immunotherapies for cancer and chronic infections. This review presents a brief overview of DC biology and of the preparation and use of DC-based vaccines.

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