Genetic variation of the mitochondrial DNA genome in American Indians is at mutation-drift equilibrium
- PMID: 1776656
- DOI: 10.1002/ajpa.1330860405
Genetic variation of the mitochondrial DNA genome in American Indians is at mutation-drift equilibrium
Abstract
Several surveys have found evidence for founder effects in Amerindian mitochondrial DNA because of the existence of rare Asian morphs in high frequencies in some Amerindian populations and the occurrence of several new morphs not seen elsewhere in the world. These reports, however, do not address whether or not the present genetic variation in the mtDNA genome in Amerindians has reached the steady-state distribution predicted by the mutation-drift theory of population genetics. The present work suggests that in three Amerindian populations (Pima, Maya, and Ticuna) a steady state has apparently been reached, and hence the initial founder effect has probably dissipated during the evolution of Amerindians in the New World. This result is consistent with the genetic variation in nuclear genes in similar populations, shown through surveys of protein variation in earlier work and, more recently, in studies of restriction fragment length polymorphisms.
Similar articles
-
American Indian prehistory as written in the mitochondrial DNA: a review.Hum Biol. 1992 Jun;64(3):403-16. Hum Biol. 1992. PMID: 1351474
-
Mitochondrial DNA diversity in the Llanos de Moxos: Moxo, Movima and Yuracare Amerindian populations from Bolivia lowlands.Ann Hum Biol. 2004 Jan-Feb;31(1):9-28. doi: 10.1080/03014460310001616464. Ann Hum Biol. 2004. PMID: 14742162
-
Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.Am J Hum Genet. 1990 Mar;46(3):613-23. Am J Hum Genet. 1990. PMID: 1968708 Free PMC article.
-
Molecular variability in Amerindians: widespread but uneven information.An Acad Bras Cienc. 2002 Jun;74(2):223-63. doi: 10.1590/s0001-37652002000200005. An Acad Bras Cienc. 2002. PMID: 12098752 Review.
-
Genetic variation in the New World: ancient teeth, bone, and tissue as sources of DNA.Experientia. 1994 Jun 15;50(6):592-601. doi: 10.1007/BF01921730. Experientia. 1994. PMID: 8020620 Review.
Cited by
-
mtDNA and Y-chromosome polymorphisms in four Native American populations from southern Mexico.Am J Hum Genet. 1994 Feb;54(2):303-18. Am J Hum Genet. 1994. PMID: 8304347 Free PMC article.
-
Population genetic structure of Ascaridia galli re-emerging in non-caged laying hens.Parasit Vectors. 2012 May 20;5:97. doi: 10.1186/1756-3305-5-97. Parasit Vectors. 2012. PMID: 22607623 Free PMC article.
-
Characteristics of polymorphism at a VNTR locus 3' to the apolipoprotein B gene in five human populations.Am J Hum Genet. 1992 Dec;51(6):1325-33. Am J Hum Genet. 1992. PMID: 1463014 Free PMC article.
-
Estimating effective population size or mutation rate with microsatellites.Genetics. 2004 Jan;166(1):555-63. doi: 10.1534/genetics.166.1.555. Genetics. 2004. PMID: 15020444 Free PMC article.
-
A concordance of nucleotide substitutions in the first and second hypervariable segments of the human mtDNA control region.Int J Legal Med. 1996;109(3):107-13. doi: 10.1007/BF01369668. Int J Legal Med. 1996. PMID: 8956982
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
