OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections
- PMID: 17721516
- DOI: 10.1038/nn1960
OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections
Abstract
The ventral telencephalon in the embryonic brain is thought to provide guidance cues for navigation of thalamocortical axons, but the mechanisms involved remain largely elusive. OL-protocadherin (OL-pc), a member of the cadherin superfamily, is highly expressed by striatal neurons in the developing ventral telencephalon. Here we show that OL-pc-deficient (Pcdh10(-/-)) mice have defects in axon pathways through the ventral telencephalon; for example, thalamocortical and corticothalamic projections cannot cross the ventral telencephalon. In the ventral telencephalon, striatal axons fail to grow out, and, concomitantly, the caudal portion of the globus pallidus and the associated 'corridor' thought to be important for thalamocortical fiber navigation do not form. The inability of the striatum to extend axons is also observed in vitro. These results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections.
Similar articles
-
Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain.Eur J Neurosci. 2012 May;35(10):1573-85. doi: 10.1111/j.1460-9568.2012.08119.x. Eur J Neurosci. 2012. PMID: 22607003 Free PMC article. Review.
-
Thalamocortical axons are influenced by chemorepellent and chemoattractant activities localized to decision points along their path.Dev Biol. 1999 Apr 15;208(2):430-40. doi: 10.1006/dbio.1999.9216. Dev Biol. 1999. PMID: 10191056
-
Molecular guidance cues necessary for axon pathfinding from the ventral cochlear nucleus.J Comp Neurol. 2007 Oct 10;504(5):533-49. doi: 10.1002/cne.21443. J Comp Neurol. 2007. PMID: 17701984
-
Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice.Neural Dev. 2009 Jun 5;4:19. doi: 10.1186/1749-8104-4-19. Neural Dev. 2009. PMID: 19500363 Free PMC article.
-
Pioneers in the ventral telencephalon: The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.Cell Adh Migr. 2007 Oct-Dec;1(4):176-8. doi: 10.4161/cam.1.4.5546. Epub 2007 Oct 8. Cell Adh Migr. 2007. PMID: 19262141 Free PMC article. Review.
Cited by
-
Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms.BMC Cancer. 2022 Apr 25;22(1):451. doi: 10.1186/s12885-022-09381-y. BMC Cancer. 2022. PMID: 35468745 Free PMC article.
-
NF-protocadherin and TAF1 regulate retinal axon initiation and elongation in vivo.J Neurosci. 2008 Jan 2;28(1):100-5. doi: 10.1523/JNEUROSCI.4490-07.2008. J Neurosci. 2008. PMID: 18171927 Free PMC article.
-
Regulation of neural circuit formation by protocadherins.Cell Mol Life Sci. 2017 Nov;74(22):4133-4157. doi: 10.1007/s00018-017-2572-3. Epub 2017 Jun 19. Cell Mol Life Sci. 2017. PMID: 28631008 Free PMC article. Review.
-
Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.Neuron. 2013 Feb 6;77(3):472-84. doi: 10.1016/j.neuron.2012.11.031. Neuron. 2013. PMID: 23395374 Free PMC article.
-
Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain.Eur J Neurosci. 2012 May;35(10):1573-85. doi: 10.1111/j.1460-9568.2012.08119.x. Eur J Neurosci. 2012. PMID: 22607003 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
