Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?
- PMID: 17720799
- DOI: 10.1136/bjsm.2007.038158
Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?
Abstract
A growing body of evidence reporting altered cardiac function and myocardial damage after arduous exercise, together with the increased prevalence of arrhythmias observed in highly trained athletes, suggests that repetitive bouts of prolonged, arduous exercise may be deleterious to long-term cardiac health. We report the case of an experienced, highly trained marathon runner who died suddenly while running. On post-mortem examination, left ventricle hypertrophy and idiopathic interstitial myocardial fibrosis was found. We believe that life-long, repetitive bouts of arduous physical activity resulted in fibrous replacement of the myocardium, causing a pathological substrate for the propagation of fatal arrhythmias.
Similar articles
-
Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?BMJ Case Rep. 2009;2009:bcr08.2008.0758. doi: 10.1136/bcr.08.2008.0758. Epub 2009 Feb 2. BMJ Case Rep. 2009. PMID: 21686644 Free PMC article.
-
Clinical significance of cardiac damage and changes in function after exercise.Med Sci Sports Exerc. 2008 Aug;40(8):1416-23. doi: 10.1249/MSS.0b013e318172cefd. Med Sci Sports Exerc. 2008. PMID: 18614951
-
Connective tissue skeleton in the normal left ventricle and in hypertensive left ventricular hypertrophy and chronic chagasic myocarditis.Med Sci Monit. 2001 Jul-Aug;7(4):820-32. Med Sci Monit. 2001. PMID: 11433216 Review.
-
[Sudden heart death in a long distance runner during a marathon].Z Kardiol. 1989 Apr;78(4):276-80. Z Kardiol. 1989. PMID: 2735089 German.
-
Imaging focal and interstitial fibrosis with cardiovascular magnetic resonance in athletes with left ventricular hypertrophy: implications for sporting participation.Br J Sports Med. 2012 Nov;46 Suppl 1:i69-77. doi: 10.1136/bjsports-2012-091482. Br J Sports Med. 2012. PMID: 23097483 Review.
Cited by
-
Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes.J Appl Physiol (1985). 2011 Jun;110(6):1622-6. doi: 10.1152/japplphysiol.01280.2010. Epub 2011 Feb 17. J Appl Physiol (1985). 2011. PMID: 21330616 Free PMC article.
-
Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.PLoS One. 2013;8(2):e55427. doi: 10.1371/journal.pone.0055427. Epub 2013 Feb 1. PLoS One. 2013. PMID: 23383330 Free PMC article.
-
Low-Intensity Exercise Modulates Gut Microbiota to Fight Against Radiation-Induced Gut Toxicity in Mouse Models.Front Cell Dev Biol. 2021 Oct 21;9:706755. doi: 10.3389/fcell.2021.706755. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34746120 Free PMC article.
-
Could Repeated Cardio-Renal Injury Trigger Late Cardiovascular Sequelae in Extreme Endurance Athletes?Sports Med. 2022 Dec;52(12):2821-2836. doi: 10.1007/s40279-022-01734-8. Epub 2022 Jul 18. Sports Med. 2022. PMID: 35851948 Free PMC article. Review.
-
Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study.J Cardiovasc Magn Reson. 2010 Jul 2;12(1):38. doi: 10.1186/1532-429X-12-38. J Cardiovasc Magn Reson. 2010. PMID: 20598139 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources