Review
doi: 10.1038/nrm2249.
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
Affiliations
- PMID: 17712357
- DOI: 10.1038/nrm2249
Item in Clipboard
Review
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
Nat Rev Mol Cell Biol.
2007 Oct.
Abstract
The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP production and consumption in all eukaryotic cells. The kinases are heterotrimers that comprise a catalytic subunit and regulatory subunits that sense cellular energy levels. When energy status is compromised, the system activates catabolic pathways and switches off protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. Surprisingly, recent results indicate that the AMPK system is also important in functions that go beyond the regulation of energy homeostasis, such as the maintenance of cell polarity in epithelial cells.
Similar articles
-
The AMP-activated protein kinase: more than an energy sensor.Essays Biochem. 2007;43:121-37. doi: 10.1042/BSE0430121. Essays Biochem. 2007. PMID: 17705797 Review.
-
AMP-activated protein kinase: the energy charge hypothesis revisited.Bioessays. 2001 Dec;23(12):1112-9. doi: 10.1002/bies.10009. Bioessays. 2001. PMID: 11746230 Review.
-
Expression and regulation of the AMP-activated protein kinase-SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits.Biochem J. 2002 Aug 1;365(Pt 3):629-38. doi: 10.1042/BJ20020124. Biochem J. 2002. PMID: 11971761 Free PMC article.
-
The AMP-activated protein kinase cascade--a unifying system for energy control.Trends Biochem Sci. 2004 Jan;29(1):18-24. doi: 10.1016/j.tibs.2003.11.005. Trends Biochem Sci. 2004. PMID: 14729328 Review.
-
[Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases].Med Sci (Paris). 2006 Apr;22(4):381-8. doi: 10.1051/medsci/2006224381. Med Sci (Paris). 2006. PMID: 16597407 Review. French.
Cited by
-
Mechanism underlying the inhibitory effect of Apelin-13 on glucose deprivation-induced autophagy in rat cardiomyocytes.Exp Ther Med. 2013 Mar;5(3):797-802. doi: 10.3892/etm.2013.902. Epub 2013 Jan 17. Exp Ther Med. 2013. PMID: 23403698 Free PMC article.
-
Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress.Mol Cell. 2015 Mar 19;57(6):1022-1033. doi: 10.1016/j.molcel.2015.01.015. Epub 2015 Feb 26. Mol Cell. 2015. PMID: 25728766 Free PMC article.
-
Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies.Cell Metab. 2013 Jan 8;17(1):101-12. doi: 10.1016/j.cmet.2012.12.006. Cell Metab. 2013. PMID: 23312286 Free PMC article.
-
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.Dis Markers. 2016;2016:3528064. doi: 10.1155/2016/3528064. Epub 2016 Apr 28. Dis Markers. 2016. PMID: 27239088 Free PMC article.
-
Antioxidant Compound, Oxyresveratrol, Inhibits APP Production through the AMPK/ULK1/mTOR-Mediated Autophagy Pathway in Mouse Cortical Astrocytes.Antioxidants (Basel). 2021 Mar 8;10(3):408. doi: 10.3390/antiox10030408. Antioxidants (Basel). 2021. PMID: 33800526 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
