Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia
- PMID: 17712030
- PMCID: PMC2779878
- DOI: 10.1093/schbul/sbm093
Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia
Abstract
The causal mechanism underlying the well-established relation between advancing paternal age and schizophrenia is hypothesized to involve mutational errors during spermatogenesis that occur with increasing frequency as males age. Point mutations are well known to increase with advancing paternal age while other errors such as altered copy number in repeat DNA and chromosome breakage have in some cases also been associated with advancing paternal age. Dysregulation of epigenetic processes may also be an important mechanism underlying the association between paternal age and schizophrenia. Evidence suggests that advancing age as well as environmental exposures alter epigenetic regulation. Errors in epigenetic processes, such as parental imprinting can have serious effects on the offspring both pre- and postnatally and into adulthood. This article will discuss parental imprinting on the autosomal and X chromosomes and the alterations in epigenetic regulation that may lead to such errors.
Similar articles
-
[Influence of paternal age in schizophrenia].Encephale. 2011 Jun;37(3):199-206. doi: 10.1016/j.encep.2010.12.005. Epub 2011 Apr 2. Encephale. 2011. PMID: 21703435 Review. French.
-
Critical periods and the developmental origins of disease: an epigenetic perspective of schizophrenia.Ann N Y Acad Sci. 2010 Sep;1204 Suppl(0):E8-13. doi: 10.1111/j.1749-6632.2010.05644.x. Ann N Y Acad Sci. 2010. PMID: 20840164 Free PMC article.
-
Epigenetic mechanisms in schizophrenia.Prog Biophys Mol Biol. 2015 Jul;118(1-2):1-7. doi: 10.1016/j.pbiomolbio.2015.04.008. Epub 2015 May 7. Prog Biophys Mol Biol. 2015. PMID: 25958205 Free PMC article. Review.
-
[Epigenetics of schizophrenia: a review].Encephale. 2014 Oct;40(5):380-6. doi: 10.1016/j.encep.2014.06.005. Epub 2014 Aug 12. Encephale. 2014. PMID: 25127897 Review. French.
-
Paternal age and intelligence: implications for age-related genomic changes in male germ cells.Psychiatr Genet. 2005 Jun;15(2):117-25. doi: 10.1097/00041444-200506000-00008. Psychiatr Genet. 2005. PMID: 15900226
Cited by
-
Fitness Consequences of Advanced Ancestral Age over Three Generations in Humans.PLoS One. 2015 Jun 1;10(6):e0128197. doi: 10.1371/journal.pone.0128197. eCollection 2015. PLoS One. 2015. PMID: 26030274 Free PMC article.
-
DNA methylation in schizophrenia: progress and challenges of epigenetic studies.Genome Med. 2012 Dec 13;4(12):96. doi: 10.1186/gm397. eCollection 2012. Genome Med. 2012. PMID: 23234572 Free PMC article. Review.
-
Parental Risk Factors among Children with Reactive Attachment Disorder Referred to Specialized Services: A Nationwide Population-Based Study.Child Psychiatry Hum Dev. 2019 Aug;50(4):546-556. doi: 10.1007/s10578-018-00861-6. Child Psychiatry Hum Dev. 2019. PMID: 30594970 Free PMC article.
-
Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective.Schizophr Res. 2011 Dec;133(1-3):120-4. doi: 10.1016/j.schres.2011.09.027. Epub 2011 Oct 14. Schizophr Res. 2011. PMID: 22000939 Free PMC article.
-
Advanced parental age at birth is associated with poorer social functioning in adolescent males: shedding light on a core symptom of schizophrenia and autism.Schizophr Bull. 2008 Nov;34(6):1042-6. doi: 10.1093/schbul/sbn109. Epub 2008 Sep 15. Schizophr Bull. 2008. PMID: 18796466 Free PMC article.
References
-
- Johansen E. A study of schizophrenia in the male. Acta Psychiatr Scand. 1958;9(suppl 125):33.
-
- Malaspina D, Harlap S, Fennig S, et al. Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry. 2001;58:361–367. - PubMed
-
- Byrne M, Agerbo E, Ewald H, Eaton WW, Mortensen PB. Parental age and risk of schizophrenia: a case-control study. Arch Gen Psychiatry. 2003;60:673–678. - PubMed
-
- Dalman C, Allebeck P. Paternal age and schizophrenia: further support for an association. Am J Psychiatry. 2002;159:1591–1592. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
