Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia
- PMID: 17712030
- PMCID: PMC2779878
- DOI: 10.1093/schbul/sbm093
Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia
Abstract
The causal mechanism underlying the well-established relation between advancing paternal age and schizophrenia is hypothesized to involve mutational errors during spermatogenesis that occur with increasing frequency as males age. Point mutations are well known to increase with advancing paternal age while other errors such as altered copy number in repeat DNA and chromosome breakage have in some cases also been associated with advancing paternal age. Dysregulation of epigenetic processes may also be an important mechanism underlying the association between paternal age and schizophrenia. Evidence suggests that advancing age as well as environmental exposures alter epigenetic regulation. Errors in epigenetic processes, such as parental imprinting can have serious effects on the offspring both pre- and postnatally and into adulthood. This article will discuss parental imprinting on the autosomal and X chromosomes and the alterations in epigenetic regulation that may lead to such errors.
Similar articles
-
[Influence of paternal age in schizophrenia].Encephale. 2011 Jun;37(3):199-206. doi: 10.1016/j.encep.2010.12.005. Epub 2011 Apr 2. Encephale. 2011. PMID: 21703435 Review. French.
-
Critical periods and the developmental origins of disease: an epigenetic perspective of schizophrenia.Ann N Y Acad Sci. 2010 Sep;1204 Suppl(0):E8-13. doi: 10.1111/j.1749-6632.2010.05644.x. Ann N Y Acad Sci. 2010. PMID: 20840164 Free PMC article.
-
Epigenetic mechanisms in schizophrenia.Prog Biophys Mol Biol. 2015 Jul;118(1-2):1-7. doi: 10.1016/j.pbiomolbio.2015.04.008. Epub 2015 May 7. Prog Biophys Mol Biol. 2015. PMID: 25958205 Free PMC article. Review.
-
[Epigenetics of schizophrenia: a review].Encephale. 2014 Oct;40(5):380-6. doi: 10.1016/j.encep.2014.06.005. Epub 2014 Aug 12. Encephale. 2014. PMID: 25127897 Review. French.
-
Paternal age and intelligence: implications for age-related genomic changes in male germ cells.Psychiatr Genet. 2005 Jun;15(2):117-25. doi: 10.1097/00041444-200506000-00008. Psychiatr Genet. 2005. PMID: 15900226
Cited by
-
Increased de novo copy number variants in the offspring of older males.Transl Psychiatry. 2011 Aug 30;1(8):e34. doi: 10.1038/tp.2011.30. Transl Psychiatry. 2011. PMID: 22832608 Free PMC article.
-
Does the concept of "sensitization" provide a plausible mechanism for the putative link between the environment and schizophrenia?Schizophr Bull. 2008 Mar;34(2):220-5. doi: 10.1093/schbul/sbm163. Epub 2008 Jan 18. Schizophr Bull. 2008. PMID: 18203757 Free PMC article. Review.
-
The effect of paternal age on offspring intelligence and personality when controlling for paternal trait level.PLoS One. 2014 Feb 25;9(2):e90097. doi: 10.1371/journal.pone.0090097. eCollection 2014. PLoS One. 2014. PMID: 24587224 Free PMC article.
-
Adoptive paternal age and risk of psychosis in adoptees: a register based cohort study.PLoS One. 2012;7(10):e47334. doi: 10.1371/journal.pone.0047334. Epub 2012 Oct 10. PLoS One. 2012. PMID: 23071791 Free PMC article.
-
Schizophrenia: from epidemiology to rehabilitation.Clin Pract Epidemiol Ment Health. 2012;8:52-66. doi: 10.2174/1745017901208010052. Epub 2012 Jul 10. Clin Pract Epidemiol Ment Health. 2012. PMID: 22962559 Free PMC article.
References
-
- Johansen E. A study of schizophrenia in the male. Acta Psychiatr Scand. 1958;9(suppl 125):33.
-
- Malaspina D, Harlap S, Fennig S, et al. Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry. 2001;58:361–367. - PubMed
-
- Byrne M, Agerbo E, Ewald H, Eaton WW, Mortensen PB. Parental age and risk of schizophrenia: a case-control study. Arch Gen Psychiatry. 2003;60:673–678. - PubMed
-
- Dalman C, Allebeck P. Paternal age and schizophrenia: further support for an association. Am J Psychiatry. 2002;159:1591–1592. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical