Review
doi: 10.1038/nrg2166.
The Decapentaplegic morphogen gradient: from pattern formation to growth regulation
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- PMID: 17703237
- DOI: 10.1038/nrg2166
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Review
The Decapentaplegic morphogen gradient: from pattern formation to growth regulation
Nat Rev Genet.
2007 Sep.
Abstract
Morphogens have been linked to numerous developmental processes, including organ patterning and the control of organ size. Here we review how different experimental approaches have led to an unprecedented level of molecular knowledge about the patterning role of the Drosophila melanogaster morphogen Decapentaplegic (DPP, the homologue of vertebrate bone morphogenetic protein, or BMP), the first validated secreted morphogen. In addition, we discuss how little is known about the role of the DPP morphogen in the control of organ growth and organ size. Continued efforts to elucidate the role of DPP in D. melanogaster is likely to shed light on this fundamental question in the near future.
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