doi: 10.1126/science.1139740.
Patched1 regulates hedgehog signaling at the primary cilium
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- PMID: 17641202
- DOI: 10.1126/science.1139740
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Patched1 regulates hedgehog signaling at the primary cilium
Science.
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Abstract
Primary cilia are essential for transduction of the Hedgehog (Hh) signal in mammals. We investigated the role of primary cilia in regulation of Patched1 (Ptc1), the receptor for Sonic Hedgehog (Shh). Ptc1 localized to cilia and inhibited Smoothened (Smo) by preventing its accumulation within cilia. When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function.
Comment in
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Cell signaling. A ciliary signaling switch.Science. 2007 Jul 20;317(5836):330-1. doi: 10.1126/science.1146180. Science. 2007. PMID: 17641189 No abstract available.
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