Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people
- PMID: 17544379
- DOI: 10.1016/j.biopsych.2007.02.012
Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people
Abstract
Background: Serotonin (5-HT) plays a central role in mood regulation and impulsivity. We studied whether healthy men and women react differently on mood and impulsivity measures during acute tryptophan depletion (ATD). We also studied the relative contribution of a functional length triallelic polymorphism in the promoter region of the serotonin transporter, designated 5-HTTLPR, to the behavioral responses to ATD.
Methods: Thirty-nine men and 44 women participated in a randomized, double-blind, parallel group ATD study. Behavioral measures of impulsivity and mood were obtained.
Results: During ATD, women reported mood reduction and showed a cautious response style, which is commonly associated with depression. Men showed an impulsive response style and did not report mood reduction. The 5-HTTLPR influenced the mood response to ATD in women.
Conclusions: Healthy men became more impulsive, whereas healthy women showed mood reduction in response to ATD. This suggests that 5-HT could be one mechanism contributing to the sex differences in the prevalence of mood and impulsivity disorders. The influence of 5-HTTLPR on mood responses in women further substantiates the relevance of this variant in the pathophysiology of at least a subgroup of patients with major depressive disorder.
Similar articles
-
Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls.Arch Gen Psychiatry. 2006 Sep;63(9):978-86. doi: 10.1001/archpsyc.63.9.978. Arch Gen Psychiatry. 2006. PMID: 16953000 Clinical Trial.
-
Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion.Mol Psychiatry. 2002;7(2):213-6. doi: 10.1038/sj.mp.4000962. Mol Psychiatry. 2002. PMID: 11840315
-
The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls.Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1263-8. doi: 10.1016/j.pnpbp.2008.03.021. Epub 2008 Apr 4. Prog Neuropsychopharmacol Biol Psychiatry. 2008. PMID: 18495314
-
Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies.Mol Psychiatry. 2007 Apr;12(4):331-59. doi: 10.1038/sj.mp.4001949. Epub 2007 Jan 16. Mol Psychiatry. 2007. PMID: 17389902 Review.
-
Neuroimaging genetics: new perspectives in research on major depression?Acta Psychiatr Scand. 2008 Nov;118(5):363-72. doi: 10.1111/j.1600-0447.2008.01225.x. Epub 2008 Jul 14. Acta Psychiatr Scand. 2008. PMID: 18644006 Review.
Cited by
-
Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and tryptophan challenge.Neuropsychopharmacology. 2011 Mar;36(4):819-26. doi: 10.1038/npp.2010.221. Epub 2010 Dec 8. Neuropsychopharmacology. 2011. PMID: 21150915 Free PMC article.
-
Pharmacogenetics of antidepressant response.J Psychiatry Neurosci. 2011 Mar;36(2):87-113. doi: 10.1503/jpn.100059. J Psychiatry Neurosci. 2011. PMID: 21172166 Free PMC article. Review.
-
A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls.Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):332-5. doi: 10.1002/ajmg.b.30984. Am J Med Genet B Neuropsychiatr Genet. 2010. PMID: 19455599 Free PMC article.
-
Epigenetics in Developmental Disorder: ADHD and Endophenotypes.J Genet Syndr Gene Ther. 2011 Jun 30;2(104):1000104. doi: 10.4172/2157-7412.1000104. J Genet Syndr Gene Ther. 2011. PMID: 22224195 Free PMC article.
-
A voxel-based morphometry study of frontal gray matter correlates of impulsivity.Hum Brain Mapp. 2009 Apr;30(4):1188-95. doi: 10.1002/hbm.20588. Hum Brain Mapp. 2009. PMID: 18465751 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
