Presence of hepatitis B virus core promoter mutations pre-seroconversion predict persistent viral replication after HBeAg loss
- PMID: 17526429
- DOI: 10.1016/j.jcv.2007.04.008
Presence of hepatitis B virus core promoter mutations pre-seroconversion predict persistent viral replication after HBeAg loss
Abstract
Background: In patients with chronic hepatitis B virus (HBV) infection DNA levels do not always fall after anti-hepatitis B e (anti-HBe) seroconversion.
Objectives: To follow longitudinally through HB e antigen (HBeAg) loss HBV DNA levels and core promoter/precore sequences in a cohort of 21 chronic HBV carriers.
Study design: Treatment-naïve HBeAg seropositive HBV carriers were monitored through HBeAg loss for between 2 and 22 years (mean 9.3). Core promoter/precore sequences, genotypes, HBV DNA levels and HBe status were determined.
Results: Patients were grouped into those in whom serum/plasma HBV DNA remained high after HBeAg loss (group 1, n=11; HBV DNA>5log(10)IU/ml) and those in whom HBV DNA declined (group 2, n=10). Re-appearance of HBeAg was seen in seven group 1 patients. Pre-seroconversion mutations in the core promoter region including A1762T and/or G1764A were detected more frequently in group 1 (P=0.031). Overall sequence changes at sites other than 1762/1764 were more common post-seroconversion in group 1 than group 2 patients (P=0.037).
Conclusions: The presence of core promoter mutations prior to HBeAg loss identified those patients in whom HBV DNA persisted at high levels and was associated with temporary re-emergence of serum HBeAg. These patients may benefit from early anti-viral treatment.
Similar articles
-
A case-control study for early prediction of hepatitis B e antigen seroconversion by hepatitis B virus DNA levels and mutations in the precore region and core promoter.J Med Virol. 2003 Aug;70(4):545-52. doi: 10.1002/jmv.10429. J Med Virol. 2003. PMID: 12794716
-
Comparative study of genotype B and C hepatitis B virus-induced chronic hepatitis in relation to the basic core promoter and precore mutations.J Gastroenterol Hepatol. 2005 Mar;20(3):441-9. doi: 10.1111/j.1440-1746.2004.03572.x. J Gastroenterol Hepatol. 2005. PMID: 15740490
-
[The prevalence and clinical significance of precore and core promoter mutations in Korean patients with chronic hepatitis B virus infection].Taehan Kan Hakhoe Chi. 2002 Jun;8(2):149-56. Taehan Kan Hakhoe Chi. 2002. PMID: 12499800 Korean.
-
Hepatitis B viral factors and clinical outcomes of chronic hepatitis B.J Biomed Sci. 2008 Mar;15(2):137-45. doi: 10.1007/s11373-007-9225-8. Epub 2007 Dec 5. J Biomed Sci. 2008. PMID: 18058038 Review.
-
The clinical implications of hepatitis B virus genotype: Recent advances.J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:123-30. doi: 10.1111/j.1440-1746.2010.06541.x. J Gastroenterol Hepatol. 2011. PMID: 21199523 Review.
Cited by
-
Impact of Hepatitis B Virus Genetic Variation, Integration, and Lymphotropism in Antiviral Treatment and Oncogenesis.Microorganisms. 2020 Sep 24;8(10):1470. doi: 10.3390/microorganisms8101470. Microorganisms. 2020. PMID: 32987867 Free PMC article. Review.
-
Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment.BMC Microbiol. 2012 Dec 28;12:307. doi: 10.1186/1471-2180-12-307. BMC Microbiol. 2012. PMID: 23272650 Free PMC article.
-
New perspective on the natural course of chronic HBV infection.Front Med. 2014 Jun;8(2):129-34. doi: 10.1007/s11684-014-0339-x. Epub 2014 May 29. Front Med. 2014. PMID: 24871442 Review.
-
Natural history and clinical management of chronic hepatitis B virus infection in children.Hepatol Int. 2008 May;2(Supplement 1):28-36. doi: 10.1007/s12072-008-9050-9. Epub 2008 Mar 6. Hepatol Int. 2008. PMID: 19669296 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
