The pars reticulata of the substantia nigra: a window to basal ganglia output
- PMID: 17499113
- DOI: 10.1016/S0079-6123(06)60009-5
The pars reticulata of the substantia nigra: a window to basal ganglia output
Abstract
Together with the internal segment of the globus pallidus (GP(i)), the pars reticulata of the substantia nigra (SNr) provides a main output nucleus of the basal ganglia (BG) where the final stage of information processing within this system takes place. In the last decade, progress on the anatomical organization and functional properties of BG output neurons have shed some light on the mechanisms of integration taking place in these nuclei and leading to normal and pathological BG outflow. In this review focused on the SNr, after describing how the anatomical arrangement of nigral cells and their afferents determines specific input-output registers, we examine how the basic electrophysiological properties of the cells and their interaction with synaptic inputs contribute to the spatio-temporal shaping of BG output. The reported data show that the intrinsic membrane properties of the neurons subserves a tonic discharge allowing BG to gate the transmission of information to motor and cognitive systems thereby contributing to appropriate selection of behavior.
Similar articles
-
GABAergic control of substantia nigra dopaminergic neurons.Prog Brain Res. 2007;160:189-208. doi: 10.1016/S0079-6123(06)60011-3. Prog Brain Res. 2007. PMID: 17499115 Review.
-
Globus pallidus external segment.Prog Brain Res. 2007;160:111-33. doi: 10.1016/S0079-6123(06)60007-1. Prog Brain Res. 2007. PMID: 17499111 Review.
-
GABAergic mechanisms in regulating the activity state of substantia nigra pars reticulata neurons.Neuroscience. 2006 Jul 21;140(4):1289-99. doi: 10.1016/j.neuroscience.2006.03.064. Epub 2006 May 19. Neuroscience. 2006. PMID: 16713116
-
The basal ganglia in Parkinson's disease: current concepts and unexplained observations.Ann Neurol. 2008 Dec;64 Suppl 2:S30-46. doi: 10.1002/ana.21481. Ann Neurol. 2008. PMID: 19127584 Review.
-
Evidence for asymmetric intra substantia nigra functional connectivity-application to basal ganglia processing.Neuroimage. 2010 Feb 15;49(4):2940-6. doi: 10.1016/j.neuroimage.2009.11.032. Epub 2009 Nov 26. Neuroimage. 2010. PMID: 19944765
Cited by
-
An integrative role for the superior colliculus in selecting targets for movements.J Neurophysiol. 2015 Oct;114(4):2118-31. doi: 10.1152/jn.00262.2015. Epub 2015 Jul 22. J Neurophysiol. 2015. PMID: 26203103 Free PMC article. Review.
-
Canceling actions involves a race between basal ganglia pathways.Nat Neurosci. 2013 Aug;16(8):1118-24. doi: 10.1038/nn.3456. Epub 2013 Jul 14. Nat Neurosci. 2013. PMID: 23852117 Free PMC article.
-
Functional circuit mapping of striatal output nuclei using simultaneous deep brain stimulation and fMRI.Neuroimage. 2017 Feb 1;146:1050-1061. doi: 10.1016/j.neuroimage.2016.10.049. Epub 2016 Nov 5. Neuroimage. 2017. PMID: 27825979 Free PMC article.
-
Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells. 2019 Aug 29;8(9):1005. doi: 10.3390/cells8091005. Cells. 2019. PMID: 31470672 Free PMC article. Review.
-
Severity of Dyskinesia and D3R Signaling Changes Induced by L-DOPA Treatment of Hemiparkinsonian Rats Are Features Inherent to the Treated Subjects.Biomolecules. 2019 Sep 1;9(9):431. doi: 10.3390/biom9090431. Biomolecules. 2019. PMID: 31480516 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
