[Neurogenesis in the adult brain]
- PMID: 17492613
[Neurogenesis in the adult brain]
Abstract
Introduction: The discovery that new neurons continue to be generated in the adult brain has modified the concept of brain plasticity and has brought to light new mechanisms that ensure the homeostasis of the nervous system.
Development: Neurogenesis, that is to say, the process involving the generation of new neurons, has been shown to occur in the hippocampus and in the olfactory bulb in adult mammals, which suggests that neuronal stem cells persist throughout the entire lifespan. The primary precursors have been identified in specialised regions called neurogenic niches. Interestingly, the cells that give rise to the new neurons in the adult brain express markers for glial cells, a cell lineage that is a long way from that of neurons. Studies conducted during the development of the brain have shown that radial glial cells not only give rise to astrocytes but also neurons, oligodendrocytes and ependymal cells. In addition, it is known that radial glial cells are also the precursors of neuronal stem cells in the adult brain.
Conclusions: Overall, these data support the idea that stem cells develop from a neuroepithelial-glial radial-astrocytic lineage. Thus, identifying the primary precursors, both in the developing brain and in the adult brain, is essential to understand the functioning of the nervous system and, from there, to develop strategies for neuronal replacement in the adult brain when needed.
Similar articles
-
Lineage analysis of quiescent regenerative stem cells in the adult brain by genetic labelling reveals spatially restricted neurogenic niches in the olfactory bulb.Eur J Neurosci. 2009 Jul;30(1):9-24. doi: 10.1111/j.1460-9568.2009.06798.x. Epub 2009 Jun 25. Eur J Neurosci. 2009. PMID: 19558606
-
Glial influences on neural stem cell development: cellular niches for adult neurogenesis.Curr Opin Neurobiol. 2005 Oct;15(5):514-20. doi: 10.1016/j.conb.2005.08.003. Curr Opin Neurobiol. 2005. PMID: 16144763 Review.
-
Glial conversion of SVZ-derived committed neuronal precursors after ectopic grafting into the adult brain.Mol Cell Neurosci. 2006 May-Jun;32(1-2):187-98. doi: 10.1016/j.mcn.2006.04.003. Epub 2006 May 30. Mol Cell Neurosci. 2006. PMID: 16730456
-
A unified hypothesis on the lineage of neural stem cells.Nat Rev Neurosci. 2001 Apr;2(4):287-93. doi: 10.1038/35067582. Nat Rev Neurosci. 2001. PMID: 11283751 Review.
-
Radial glial origin of the adult neural stem cells in the subventricular zone.Prog Neurobiol. 2007 Sep;83(1):24-36. doi: 10.1016/j.pneurobio.2006.11.002. Epub 2006 Dec 29. Prog Neurobiol. 2007. PMID: 17196731 Review.
Cited by
-
Basic mechanisms of rTMS: Implications in Parkinson's disease.Int Arch Med. 2008 Apr 15;1(1):2. doi: 10.1186/1755-7682-1-2. Int Arch Med. 2008. PMID: 18471317 Free PMC article.
-
Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective.Front Neurosci. 2023 Aug 10;17:1214468. doi: 10.3389/fnins.2023.1214468. eCollection 2023. Front Neurosci. 2023. PMID: 37638319 Free PMC article. Review.
-
Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells.PLoS One. 2013 Oct 17;8(10):e76860. doi: 10.1371/journal.pone.0076860. eCollection 2013. PLoS One. 2013. PMID: 24146937 Free PMC article.
-
Mobilization of neural stem cells and generation of new neurons in 6-OHDA-lesioned rats by intracerebroventricular infusion of liver growth factor.J Histochem Cytochem. 2009 May;57(5):491-502. doi: 10.1369/jhc.2009.952275. Epub 2009 Feb 2. J Histochem Cytochem. 2009. PMID: 19188487 Free PMC article.
-
Curcumin Stimulates Proliferation of Spinal Cord Neural Progenitor Cells via a Mitogen-Activated Protein Kinase Signaling Pathway.J Korean Neurosurg Soc. 2014 Jul;56(1):1-4. doi: 10.3340/jkns.2014.56.1.1. Epub 2014 Jul 31. J Korean Neurosurg Soc. 2014. PMID: 25289117 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Medical