The interrelations among feeding, circadian rhythms and ageing
- PMID: 17482337
- DOI: 10.1016/j.pneurobio.2007.03.002
The interrelations among feeding, circadian rhythms and ageing
Abstract
The master clock located in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus in the brain regulates circadian rhythms in mammals. Similar circadian oscillators have been found in peripheral tissues, such as the liver, intestine and retina. Life span has been previously linked independently to both circadian rhythms and caloric restriction (CR). The mechanisms by which CR attenuates ageing and extends life span are virtually unknown. It has recently been found that the alphaMUPA mice, transgenic mice that exhibit spontaneously reduced eating and live longer compared to their FVB/N wild-type control mice, show high amplitude, appropriately reset circadian rhythms. These pronounced rhythms were found both in clock gene expression in the liver and clock-controlled output systems, such as feeding time and body temperature. Furthermore, it was previously shown that CR could reset the central biological clock in the SCN. As the circadian clock in the SCN controls many physiological and biochemical systems, we suggest that appropriately reset peripheral rhythms could constitute an important mediator of longevity in calorically restricted animals. Thus, we suggest that three parameters, i.e., caloric restriction, circadian rhythms and life span, are interconnected. This surmise is novel, and we provide evidence to support it. Furthermore, we discuss other feeding regimens and their effects on circadian rhythms and/or life span.
Similar articles
-
Long-lived alphaMUPA transgenic mice exhibit pronounced circadian rhythms.Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1017-24. doi: 10.1152/ajpendo.00140.2006. Epub 2006 Jun 20. Am J Physiol Endocrinol Metab. 2006. PMID: 16787960
-
Relationship between calorie restriction and the biological clock: lessons from long-lived transgenic mice.Rejuvenation Res. 2008 Apr;11(2):467-71. doi: 10.1089/rej.2008.0669. Rejuvenation Res. 2008. PMID: 18321196 Review.
-
Effect of intermittent fasting on circadian rhythms in mice depends on feeding time.Mech Ageing Dev. 2009 Mar;130(3):154-60. doi: 10.1016/j.mad.2008.10.006. Epub 2008 Nov 8. Mech Ageing Dev. 2009. PMID: 19041664
-
Circadian and photic regulation of clock and clock-controlled proteins in the suprachiasmatic nuclei of calorie-restricted mice.Eur J Neurosci. 2007 Jun;25(12):3691-701. doi: 10.1111/j.1460-9568.2007.05626.x. Eur J Neurosci. 2007. PMID: 17610588
-
The relationship between nutrition and circadian rhythms in mammals.Front Neuroendocrinol. 2007 Aug-Sep;28(2-3):61-71. doi: 10.1016/j.yfrne.2007.03.001. Epub 2007 Mar 24. Front Neuroendocrinol. 2007. PMID: 17451793 Review.
Cited by
-
Long-Lived αMUPA Mice Show Attenuation of Cardiac Aging and Leptin-Dependent Cardioprotection.PLoS One. 2015 Dec 16;10(12):e0144593. doi: 10.1371/journal.pone.0144593. eCollection 2015. PLoS One. 2015. PMID: 26673217 Free PMC article.
-
Antiaging diets: Separating fact from fiction.Science. 2021 Nov 19;374(6570):eabe7365. doi: 10.1126/science.abe7365. Epub 2021 Nov 19. Science. 2021. PMID: 34793210 Free PMC article. Review.
-
Measurement of internal body time by blood metabolomics.Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9890-5. doi: 10.1073/pnas.0900617106. Epub 2009 Jun 1. Proc Natl Acad Sci U S A. 2009. PMID: 19487679 Free PMC article.
-
Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline.Oncotarget. 2015 Sep 15;6(27):23181-203. doi: 10.18632/oncotarget.4036. Oncotarget. 2015. PMID: 26252151 Free PMC article. Review.
-
Ayurveda and the science of aging.J Ayurveda Integr Med. 2018 Jul-Sep;9(3):225-232. doi: 10.1016/j.jaim.2017.10.002. Epub 2017 Dec 21. J Ayurveda Integr Med. 2018. PMID: 29276113 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
