Review
doi: 10.1038/nrm2162.
The emerging shape of the ESCRT machinery
Affiliations
- PMID: 17450176
- DOI: 10.1038/nrm2162
Item in Clipboard
Review
The emerging shape of the ESCRT machinery
Nat Rev Mol Cell Biol.
2007 May.
Abstract
The past two years have seen an explosion in the structural understanding of the endosomal sorting complex required for transport (ESCRT) machinery that facilitates the trafficking of ubiquitylated proteins from endosomes to lysosomes via multivesicular bodies (MVBs). A common organization of all ESCRTs is a rigid core attached to flexibly connected modules that recognize other components of the MVB pathway. Several previously unsuspected key links between multiple ESCRT subunits, phospholipids and ubiquitin have now been elucidated, which, together with the detailed morphological analyses of ESCRT-depletion phenotypes, provide new insights into the mechanism of MVB biogenesis.
Similar articles
-
Endosomal and non-endosomal functions of ESCRT proteins.Trends Cell Biol. 2006 Jun;16(6):317-26. doi: 10.1016/j.tcb.2006.04.004. Epub 2006 May 22. Trends Cell Biol. 2006. PMID: 16716591 Review.
-
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.Cell. 2006 Apr 7;125(1):99-111. doi: 10.1016/j.cell.2006.01.047. Cell. 2006. PMID: 16615893
-
A concentric circle model of multivesicular body cargo sorting.EMBO Rep. 2007 Jul;8(7):644-50. doi: 10.1038/sj.embor.7401004. EMBO Rep. 2007. PMID: 17603537 Free PMC article. Review.
-
ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting.J Cell Biol. 2009 Apr 20;185(2):213-24. doi: 10.1083/jcb.200811130. J Cell Biol. 2009. PMID: 19380877 Free PMC article.
-
Critical role of ESCRT machinery in EGFR recycling.Biochemistry. 2009 Oct 13;48(40):9321-3. doi: 10.1021/bi900865u. Biochemistry. 2009. PMID: 19673488
Cited by
-
Vesicle formation within endosomes: An ESCRT marks the spot.Commun Integr Biol. 2012 Jan 1;5(1):50-6. doi: 10.4161/cib.18208. Commun Integr Biol. 2012. PMID: 22482010 Free PMC article.
-
Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway.J Biol Chem. 2012 Dec 21;287(52):43899-908. doi: 10.1074/jbc.M112.390724. Epub 2012 Oct 26. J Biol Chem. 2012. PMID: 23105107 Free PMC article.
-
Ubiquitination: Added complexity in Ras and Rho family GTPase function.Small GTPases. 2011 Jul;2(4):192-201. doi: 10.4161/sgtp.2.4.16707. Epub 2011 Jul 1. Small GTPases. 2011. PMID: 22145091 Free PMC article.
-
Exosomes or microvesicles? Two kinds of extracellular vesicles with different routes to modify protozoan-host cell interaction.Parasitol Res. 2015 Oct;114(10):3567-75. doi: 10.1007/s00436-015-4659-9. Epub 2015 Aug 15. Parasitol Res. 2015. PMID: 26272631 Review.
-
Endocytic pathway is required for Drosophila Toll innate immune signaling.Proc Natl Acad Sci U S A. 2010 May 4;107(18):8322-7. doi: 10.1073/pnas.1004031107. Epub 2010 Apr 19. Proc Natl Acad Sci U S A. 2010. PMID: 20404143 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
