Review
doi: 10.4161/cc.6.9.4229.
Epub 2007 May 2.
The role of angiopoietin 2 in hyperoxia-induced acute lung injury
Affiliations
- PMID: 17438375
- DOI: 10.4161/cc.6.9.4229
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Review
The role of angiopoietin 2 in hyperoxia-induced acute lung injury
Cell Cycle.
.
Abstract
Hyperoxia-induced acute lung injury (HALI) is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. In a murine model and in vitro, we found Angiopoietin 2 to be a critical mediator of lung oxidant injury, inflammation, edema, and regulator of necrotic cell death pathways. The clinical significance of our findings was highlighted by the detection of increased Angiopoietin 2 levels in patients with ALI.
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