Novel aspects of G-protein-coupled receptor signalling--different ways to achieve specificity
- PMID: 17428230
- DOI: 10.1111/j.1365-201X.2007.01696.x
Novel aspects of G-protein-coupled receptor signalling--different ways to achieve specificity
Abstract
Our understanding of signal transduction via G-protein-coupled receptors (GPCR) has developed dramatically during the last decades. The initial idea of linear signalling pathways transferring information from the cell membrane to the nucleus has evolved into a complicated network of signalling pathways offering the possibility of crosstalk, fine tuning and specific regulation at multiple levels. During the recent meeting on GPCRs at the Karolinska Institutet, Stockholm novel aspects of GPCR signalling were presented and discussed. Here, we will discuss several possibilities for GPCRs to achieve specificity in signal transduction, such as the phenomenon of biased agonism, receptor multimerization, the role of co-receptors, the regulation of heterotrimeric G proteins as well as multiple G(s)-dependent pathways to extracellular single-regulated protein kinases.
Similar articles
-
GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activation.Trends Pharmacol Sci. 2007 Dec;28(12):602-7. doi: 10.1016/j.tips.2007.09.007. Epub 2007 Nov 14. Trends Pharmacol Sci. 2007. PMID: 18001849 Review.
-
Mitogenic signaling pathways induced by G protein-coupled receptors.J Cell Physiol. 2007 Dec;213(3):589-602. doi: 10.1002/jcp.21246. J Cell Physiol. 2007. PMID: 17786953 Review.
-
Small GTP-binding protein-coupled receptors.Biochem Soc Trans. 2004 Dec;32(Pt 6):1040-4. doi: 10.1042/BST0321040. Biochem Soc Trans. 2004. PMID: 15506958 Review.
-
G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation.Trends Endocrinol Metab. 2006 Mar;17(2):48-54. doi: 10.1016/j.tem.2006.01.006. Epub 2006 Feb 7. Trends Endocrinol Metab. 2006. PMID: 16460957 Review.
-
Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins.Eur J Pharmacol. 2008 May 13;585(2-3):278-91. doi: 10.1016/j.ejphar.2008.02.088. Epub 2008 Mar 15. Eur J Pharmacol. 2008. PMID: 18410914 Review.
Cited by
-
Molecular mechanisms underlying β-adrenergic receptor-mediated cross-talk between sympathetic neurons and immune cells.Int J Mol Sci. 2015 Mar 11;16(3):5635-65. doi: 10.3390/ijms16035635. Int J Mol Sci. 2015. PMID: 25768345 Free PMC article. Review.
-
Melatonin receptor expression in Xenopus laevis surface corneal epithelium: diurnal rhythm of lateral membrane localization.Mol Vis. 2009 Nov 17;15:2384-403. Mol Vis. 2009. PMID: 19936310 Free PMC article.
-
A Paradigm for Peptide Hormone-GPCR Analyses.Molecules. 2020 Sep 18;25(18):4272. doi: 10.3390/molecules25184272. Molecules. 2020. PMID: 32961885 Free PMC article. Review.
-
GPR11, a putative seven-transmembrane G protein-coupled receptor, controls zoospore development and virulence of Phytophthora sojae.Eukaryot Cell. 2010 Feb;9(2):242-50. doi: 10.1128/EC.00265-09. Epub 2009 Dec 11. Eukaryot Cell. 2010. PMID: 20008081 Free PMC article.
-
Epistatic effects of multiple receptor genes on pathophysiology of asthma - its limits and potential for clinical application.Med Sci Monit. 2014 Jan 17;20:64-71. doi: 10.12659/MSM.889754. Med Sci Monit. 2014. PMID: 24435185 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
