Linking the epigenetic 'language' of covalent histone modifications to cancer
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- PMID: 17393583
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Linking the epigenetic 'language' of covalent histone modifications to cancer
Br J Cancer.
2007.
Abstract
Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human biology and human health. This review focuses on how aberrant covalent histone modifications may contribute to the development of a variety of human cancers, and discusses the recent findings with regard to potential therapies.
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Linking the epigenetic 'language' of covalent histone modifications to cancer.Br J Cancer. 2004 Feb 23;90(4):761-9. doi: 10.1038/sj.bjc.6601575. Br J Cancer. 2004. PMID: 14970850 Free PMC article. Review.
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