Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients
- PMID: 17386345
- DOI: 10.1016/j.amjhyper.2006.09.021
Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients
Abstract
Background: Essential hypertension is characterized by endothelial dysfunction, arterial stiffness, and increased oxidative stress. We evaluated the effect of short-term combined treatment with the antioxidants vitamins C and E on endothelial function, arterial stiffness, and oxidative stress in untreated essential hypertensive patients.
Methods: A randomized, double-blind, placebo-controlled, crossover study design was used to assign 30 male essential hypertensive patients to either vitamin C (1 g) and vitamin E (400 IU) or placebo for 8 weeks. Endothelium-dependent response was assessed as flow-mediated dilation (FMD) of the brachial artery. Arterial stiffness was assessed as central pulse wave velocity (PWV) and augmentation index (AIx). Plasma markers of oxidative stress and antioxidant status were measured.
Results: After vitamin supplementation, FMD was significantly improved. Central PWV was significantly reduced, while AIx tended to decrease. Plasma vitamin levels and antioxidant capacity increased significantly. Levels of oxidative stress decreased. Changes in central PWV were related to changes in levels of oxidative stress.
Conclusions: Combined treatment with vitamins C and E has beneficial effects on endothelium-dependent vasodilation and arterial stiffness in untreated, essential hypertensive patients. This effect is associated with changes in plasma markers of oxidative stress.
Similar articles
-
Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study.J Rheumatol. 2005 Feb;32(2):275-82. J Rheumatol. 2005. PMID: 15693087 Clinical Trial.
-
Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function.J Am Coll Cardiol. 2004 Feb 18;43(4):629-34. doi: 10.1016/j.jacc.2003.08.051. J Am Coll Cardiol. 2004. PMID: 14975474 Clinical Trial.
-
Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension.Clin Sci (Lond). 2008 May;114(10):625-34. doi: 10.1042/CS20070343. Clin Sci (Lond). 2008. PMID: 17999638 Clinical Trial.
-
Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice.Herz. 2003 Nov;28(7):628-38. doi: 10.1007/s00059-003-2417-8. Herz. 2003. PMID: 14689123 Review.
-
Clinical pharmacology and therapeutic use of antioxidant vitamins.Fundam Clin Pharmacol. 2007 Apr;21(2):111-27. doi: 10.1111/j.1472-8206.2006.00466.x. Fundam Clin Pharmacol. 2007. PMID: 17391284 Review.
Cited by
-
Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function.Oxid Med Cell Longev. 2020 Sep 26;2020:1496462. doi: 10.1155/2020/1496462. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 33062134 Free PMC article. Review.
-
Run for your life: exercise, oxidative stress and the ageing endothelium.J Physiol. 2009 Sep 1;587(Pt 17):4137-8. doi: 10.1113/jphysiol.2009.178624. J Physiol. 2009. PMID: 19720852 Free PMC article. No abstract available.
-
Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans.Inflammation. 2023 Aug;46(4):1343-1352. doi: 10.1007/s10753-023-01801-w. Epub 2023 Mar 20. Inflammation. 2023. PMID: 36935449 Free PMC article.
-
The Comparative Effects of Different Types of Oral Vitamin Supplements on Arterial Stiffness: A Network Meta-Analysis.Nutrients. 2022 Feb 27;14(5):1009. doi: 10.3390/nu14051009. Nutrients. 2022. PMID: 35267985 Free PMC article. Review.
-
Obesity, cardiovascular disease, and role of vitamin C on inflammation: a review of facts and underlying mechanisms.Inflammopharmacology. 2017 Jun;25(3):313-328. doi: 10.1007/s10787-017-0314-7. Epub 2017 Feb 6. Inflammopharmacology. 2017. PMID: 28168552 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
