Review
doi: 10.1016/j.biochi.2007.01.013.
Epub 2007 Feb 20.
Triggering antiviral response by RIG-I-related RNA helicases
Affiliations
- PMID: 17379377
- DOI: 10.1016/j.biochi.2007.01.013
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Review
Triggering antiviral response by RIG-I-related RNA helicases
Biochimie.
2007 Jun-Jul.
Abstract
TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses.
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