The Akt-GSK-3 signaling cascade in the actions of dopamine
- PMID: 17349698
- DOI: 10.1016/j.tips.2007.02.006
The Akt-GSK-3 signaling cascade in the actions of dopamine
Abstract
Drugs that act on dopamine neurotransmission are important tools for the management of multiple neuropsychiatric disorders. Classically, dopamine receptors have been shown to regulate cAMP-PKA (protein kinase A) and Ca(2+) pathways through G-protein-mediated signaling. However, it has become apparent that, in addition to this canonical action, D(2)-class dopamine receptors can function through a protein kinase B (Akt)-GSK-3 (glycogen synthase kinase 3) signaling cascade. This novel signaling mode involves the multifunctional scaffolding protein beta-arrestin 2, which has a role in G-protein-coupled receptor (GPCR) desensitization. In this article, we provide an overview of how this dual function of components of the GPCR desensitization machinery relates to dopamine-receptor-mediated responses and we summarize recent insights into the relevance of the Akt-GSK-3 signaling cascade for the expression of dopamine-associated behaviors and the actions of dopaminergic drugs.
Similar articles
-
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.Cell. 2005 Jul 29;122(2):261-73. doi: 10.1016/j.cell.2005.05.012. Cell. 2005. PMID: 16051150
-
α-Lipoic acid interaction with dopamine D2 receptor-dependent activation of the Akt/GSK-3β signaling pathway induced by antipsychotics: potential relevance for the treatment of schizophrenia.J Mol Neurosci. 2013 May;50(1):134-45. doi: 10.1007/s12031-012-9884-4. Epub 2012 Sep 14. J Mol Neurosci. 2013. PMID: 22975849
-
GSK-3β activity and hyperdopamine-dependent behaviors.Neurosci Biobehav Rev. 2011 Jan;35(3):645-54. doi: 10.1016/j.neubiorev.2010.08.001. Epub 2010 Aug 18. Neurosci Biobehav Rev. 2011. PMID: 20727368 Free PMC article. Review.
-
A beta-arrestin 2 signaling complex mediates lithium action on behavior.Cell. 2008 Jan 11;132(1):125-36. doi: 10.1016/j.cell.2007.11.041. Cell. 2008. PMID: 18191226
-
Akt/GSK3 signaling in the action of psychotropic drugs.Annu Rev Pharmacol Toxicol. 2009;49:327-47. doi: 10.1146/annurev.pharmtox.011008.145634. Annu Rev Pharmacol Toxicol. 2009. PMID: 18928402 Review.
Cited by
-
Potential Roles of Adropin in Central Nervous System: Review of Current Literature.Front Mol Biosci. 2016 Jun 27;3:25. doi: 10.3389/fmolb.2016.00025. eCollection 2016. Front Mol Biosci. 2016. PMID: 27446928 Free PMC article. Review.
-
Presynaptic inhibition of olfactory sensory neurons: new mechanisms and potential functions.Chem Senses. 2013 Jul;38(6):459-74. doi: 10.1093/chemse/bjt018. Epub 2013 Jun 11. Chem Senses. 2013. PMID: 23761680 Free PMC article. Review.
-
Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson's Disease.Front Aging Neurosci. 2016 Mar 30;8:65. doi: 10.3389/fnagi.2016.00065. eCollection 2016. Front Aging Neurosci. 2016. PMID: 27065205 Free PMC article. Review.
-
Dopamine receptors - IUPHAR Review 13.Br J Pharmacol. 2015 Jan;172(1):1-23. doi: 10.1111/bph.12906. Br J Pharmacol. 2015. PMID: 25671228 Free PMC article. Review.
-
Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients.PLoS One. 2012;7(2):e32618. doi: 10.1371/journal.pone.0032618. Epub 2012 Feb 29. PLoS One. 2012. PMID: 22393424 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
