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Review
. 2007 Mar;33(2):159-64.
doi: 10.1055/s-2007-969029.

Platelets and stromal cell-derived factor-1 in progenitor cell recruitment

Konstantinos Stellos  1 , Meinrad Gawaz
Affiliations
Review

Platelets and stromal cell-derived factor-1 in progenitor cell recruitment

Konstantinos Stellos et al. Semin Thromb Hemost. 2007 Mar.

Abstract

Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that binds to its sole counterreceptor, CXCR4. It is well reported that the SDF-1/CXCR4 signaling pathway is of vital importance to human development and to various pathophysiological phenomena, including hematopoiesis, angiogenesis, atherosclerosis, cancer growth, metastasis, and human immunodeficiency virus infection. SDF-1 promotes mobilization of bone marrow-derived endothelial progenitor cells (EPCs) to the circulation in response to vascular injury. Recently, we found that platelets express and release SDF-1 into the microcirculation upon activation and we observed that platelet-derived SDF-1 is functionally involved in recruitment of EPCs to arterial thrombi in vivo. This review discusses the unique functions of this chemokine and the newly discovered impact of platelet-derived SDF-1 into the recruitment of progenitor cells to vascular injury areas, and its subsequent effects in atherosclerosis, vascular repair, and angiogenesis.

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