A beta oligomers - a decade of discovery
- PMID: 17286590
- DOI: 10.1111/j.1471-4159.2006.04426.x
A beta oligomers - a decade of discovery
Abstract
Converging lines of evidence suggest that progressive accumulation of the amyloid beta-protein (A beta) plays a central role in the genesis of Alzheimer's disease, but it was long assumed that A beta had to be assembled into extracellular amyloid fibrils to exert its cytotoxic effects. Over the past decade, data have emerged from the use of synthetic A beta peptides, cell culture models, beta-amyloid precursor protein transgenic mice and human brain to suggest that pre-fibrillar, diffusible assemblies of A beta are also deleterious. Although the precise molecular identity of these soluble toxins remains unsettled, accumulating evidence suggests that soluble forms of A beta are indeed the proximate effectors of synapse loss and neuronal injury. Here we review recent progress in understanding the role of soluble oligomers in Alzheimer's disease.
Similar articles
-
Low-n oligomers as therapeutic targets of Alzheimer's disease.J Neurochem. 2011 Apr;117(1):19-28. doi: 10.1111/j.1471-4159.2011.07187.x. Epub 2011 Feb 9. J Neurochem. 2011. PMID: 21244429 Review.
-
A molecular approach to Alzheimer's disease.Biol Chem Hoppe Seyler. 1993 Jan;374(1):1-8. Biol Chem Hoppe Seyler. 1993. PMID: 8439394 Review. No abstract available.
-
Soluble amyloid beta oligomers may contribute to apoptosis of retinal ganglion cells in glaucoma.Med Hypotheses. 2008;71(1):77-80. doi: 10.1016/j.mehy.2008.01.030. Epub 2008 Apr 11. Med Hypotheses. 2008. PMID: 18406539
-
Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.IUBMB Life. 2007 Apr-May;59(4-5):332-45. doi: 10.1080/15216540701283882. IUBMB Life. 2007. PMID: 17505973 Review.
-
Intracellular amyloid-beta in Alzheimer's disease.Nat Rev Neurosci. 2007 Jul;8(7):499-509. doi: 10.1038/nrn2168. Nat Rev Neurosci. 2007. PMID: 17551515 Review.
Cited by
-
In vivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer's Aβ protein.Front Aging Neurosci. 2016 Sep 27;8:223. doi: 10.3389/fnagi.2016.00223. eCollection 2016. Front Aging Neurosci. 2016. PMID: 27729857 Free PMC article.
-
Lithium reduces BACE1 overexpression, β amyloid accumulation, and spatial learning deficits in mice with traumatic brain injury.J Neurotrauma. 2012 Sep;29(13):2342-51. doi: 10.1089/neu.2012.2449. Epub 2012 Jul 2. J Neurotrauma. 2012. PMID: 22583494 Free PMC article.
-
Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons.PLoS One. 2015 May 29;10(5):e0128366. doi: 10.1371/journal.pone.0128366. eCollection 2015. PLoS One. 2015. PMID: 26024517 Free PMC article.
-
Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus.PLoS One. 2012;7(1):e29661. doi: 10.1371/journal.pone.0029661. Epub 2012 Jan 11. PLoS One. 2012. PMID: 22253754 Free PMC article.
-
Alzheimer disease and platelets: how's that relevant.Immun Ageing. 2012 Sep 17;9(1):20. doi: 10.1186/1742-4933-9-20. Immun Ageing. 2012. PMID: 22985434 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
