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Review
. 2007;9(1):301.
doi: 10.1186/ar2103.

Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

Alan Tyndall  1 , Ulrich A Walker, Andrew Cope, Francesco Dazzi, Cosimo De Bari, Willem Fibbe, Serena Guiducci, Simon Jones, Christian Jorgensen, Katarina Le Blanc, Frank Luyten, Dennis McGonagle, Ivan Martin, Chiara Bocelli-Tyndall, Giuseppina Pennesi, Vito Pistoia, Constantino Pitzalis, Antonio Uccelli, Nico Wulffraat, Marc Feldmann
Affiliations
Review

Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

Alan Tyndall et al. Arthritis Res Ther. 2007.

Abstract

Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines--an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.

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Figures

Figure 1
Figure 1
Trilineage differentiation of MSCs. Images by courtesy of Ivan Martin. DMEM, Dulbecco's modified Eagle medium; ITS, insulin transferring selenous acid; MSC, mesenchymal stem cell (multipotent mesenchymal stromal cell); TGF, transforming growth factor.
See this image and copyright information in PMC

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