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. 2007 Aug;93(8):940-4.
doi: 10.1136/hrt.2006.101949. Epub 2007 Jan 19.

Heart rate and microinflammation in men: a relevant atherothrombotic link

O Rogowski  1 , I Shapira, A Shirom, S Melamed, S Toker, S Berliner
Affiliations

Heart rate and microinflammation in men: a relevant atherothrombotic link

O Rogowski et al. Heart. 2007 Aug.

Abstract

Objective and background: To explore the possibility that increased resting heart rate (HR) is associated with a microinflammatory response. Such an association could explain, at least in part, the recently described worse cardiovascular prognosis in individuals with increased HR.

Methods: Concentrations of fibrinogen and high-sensitivity C-reactive protein, as well as the absolute number of polymorphonuclear leucocytes, were analysed in a cohort of 4553 apparently healthy men and in those with atherothrombotic risk factors.

Results: Following adjustment for age and body mass index, lipid profile and cardiovascular risk factors, a significant (p<0.001) difference was noted between individuals in the first quintile of HR (< or =58 beats/min) and those in the fifth quintile (> or =79 beats/min) regarding all the above-mentioned inflammatory biomarkers, the respective mean values being 7.38 and 8.11 micromol/l, 1.12 and 1.61 mg/l, and 4.23 and 4.74 x 10(9)/l.

Conclusions: Resting HR is associated with a microinflammatory response in apparently healthy men and in those with atherothrombotic risk factors. Sympathetic activation might be a common factor explaining such an association. If confirmed in additional studies, this association might be a relevant target for therapeutic manipulations.

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Conflict of interest statement

Competing interests: None declared.

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