Heart rate and microinflammation in men: a relevant atherothrombotic link
- PMID: 17237129
- PMCID: PMC1994422
- DOI: 10.1136/hrt.2006.101949
Heart rate and microinflammation in men: a relevant atherothrombotic link
Abstract
Objective and background: To explore the possibility that increased resting heart rate (HR) is associated with a microinflammatory response. Such an association could explain, at least in part, the recently described worse cardiovascular prognosis in individuals with increased HR.
Methods: Concentrations of fibrinogen and high-sensitivity C-reactive protein, as well as the absolute number of polymorphonuclear leucocytes, were analysed in a cohort of 4553 apparently healthy men and in those with atherothrombotic risk factors.
Results: Following adjustment for age and body mass index, lipid profile and cardiovascular risk factors, a significant (p<0.001) difference was noted between individuals in the first quintile of HR (< or =58 beats/min) and those in the fifth quintile (> or =79 beats/min) regarding all the above-mentioned inflammatory biomarkers, the respective mean values being 7.38 and 8.11 micromol/l, 1.12 and 1.61 mg/l, and 4.23 and 4.74 x 10(9)/l.
Conclusions: Resting HR is associated with a microinflammatory response in apparently healthy men and in those with atherothrombotic risk factors. Sympathetic activation might be a common factor explaining such an association. If confirmed in additional studies, this association might be a relevant target for therapeutic manipulations.
Conflict of interest statement
Competing interests: None declared.
Similar articles
-
Resting heart rate is associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers: the Copenhagen City Heart Study.Eur J Prev Cardiol. 2012 Feb;19(1):102-8. doi: 10.1177/1741826710394274. Epub 2011 Apr 27. Eur J Prev Cardiol. 2012. PMID: 21525123
-
High-sensitivity C-reactive protein measurements in patients with non-arteritic anterior ischaemic optic neuropathy: a clue to the presence of a microinflammatory response.Acta Ophthalmol. 2009 Mar;87(2):216-21. doi: 10.1111/j.1755-3768.2008.01199.x. Epub 2008 Jun 18. Acta Ophthalmol. 2009. PMID: 18577187
-
Psychosocial factors and inflammation in the multi-ethnic study of atherosclerosis.Arch Intern Med. 2007 Jan 22;167(2):174-81. doi: 10.1001/archinte.167.2.174. Arch Intern Med. 2007. PMID: 17242319
-
Exploring the usefulness of inflammation-sensitive biomarkers to reveal potential sex differences in relation to low-grade inflammation in individuals with the metabolic syndrome.Metabolism. 2008 Sep;57(9):1221-6. doi: 10.1016/j.metabol.2008.04.015. Metabolism. 2008. PMID: 18702947
-
Arterial stiffness and inflammatory response to psychophysiological stress.Brain Behav Immun. 2008 Aug;22(6):941-8. doi: 10.1016/j.bbi.2008.01.009. Epub 2008 Mar 7. Brain Behav Immun. 2008. PMID: 18316176
Cited by
-
Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study.BMC Cardiovasc Disord. 2020 Jul 6;20(1):319. doi: 10.1186/s12872-020-01594-y. BMC Cardiovasc Disord. 2020. PMID: 32631242 Free PMC article.
-
Psychophysiological correlates of systemic inflammation in black and white men.Brain Behav Immun. 2017 Jan;59:93-102. doi: 10.1016/j.bbi.2016.08.013. Epub 2016 Aug 24. Brain Behav Immun. 2017. PMID: 27568363 Free PMC article.
-
Association between resting heart rate and inflammatory biomarkers (high-sensitivity C-reactive protein, interleukin-6, and fibrinogen) (from the Multi-Ethnic Study of Atherosclerosis).Am J Cardiol. 2014 Feb 15;113(4):644-9. doi: 10.1016/j.amjcard.2013.11.009. Epub 2013 Nov 23. Am J Cardiol. 2014. PMID: 24393259 Free PMC article.
-
The inverse association between cardiorespiratory fitness and C-reactive protein is mediated by autonomic function: a possible role of the cholinergic antiinflammatory pathway.Mol Med. 2009 Sep-Oct;15(9-10):291-6. doi: 10.2119/molmed.2009.00057. Epub 2009 Jun 6. Mol Med. 2009. PMID: 19603105 Free PMC article.
-
Ivabradine, coronary artery disease, and heart failure: beyond rhythm control.Drug Des Devel Ther. 2014 Jun 3;8:689-700. doi: 10.2147/DDDT.S60591. eCollection 2014. Drug Des Devel Ther. 2014. PMID: 24940047 Free PMC article. Review.
References
-
- Palatini P. Heart rate: a strong predictor of mortality in subjects with coronary artery disease. Eur Heart J 200526943–945. - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials