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Review
. 2007 Jan 15:4:8.
doi: 10.1186/1743-422X-4-8.

From actually toxic to highly specific--novel drugs against poxviruses

Katja Sliva  1 , Barbara Schnierle
Affiliations
Review

From actually toxic to highly specific--novel drugs against poxviruses

Katja Sliva et al. Virol J. .

Abstract

The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral infections have been less successful than those targeting bacterial infections. While bacteria commonly reproduce themselves outside of cells and have metabolic functions against which antibiotics can be directed, viruses replicate in the host cells using the cells' metabolic pathways. This makes it very difficult to selectively target the virus without damaging the host. Therefore, the development of antiviral drugs against poxviruses has initially focused on unique properties of the viral replication cycle or of viral proteins that can be selectively targeted. However, recent advances in molecular biology have provided insights into host factors that represent novel drug targets. The latest anti-poxvirus drugs are kinase inhibitors, which were originally developed to treat cancer progression but in addition block egress of poxviruses from infected cells. This review will summarize the current understanding of anti-poxvirus drugs and will give an overview of the development of the latest second generation poxvirus drugs.

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Figures

Figure 1
Figure 1
Schematic overview of the VACV replication cycle, the different virion forms and the point of action of anti-poxvirus drugs.
See this image and copyright information in PMC

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