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. 2007 Feb;54(2):119-23.
doi: 10.1007/s00284-006-0215-2. Epub 2007 Jan 5.

Absence of classical heat shock response in the citrus pathogen Xylella fastidiosa

Daniel Martins-de-Souza  1 , Gustavo Astua-Monge, Helvécio Della Coletta-Filho, Flavia Vischi Winck, Paulo Aparecido Baldasso, Bruno Menezes de Oliveira, Sérgio Marangoni, Marcos Antônio Machado, José Camillo Novello, Marcus Bustamante Smolka
Affiliations

Absence of classical heat shock response in the citrus pathogen Xylella fastidiosa

Daniel Martins-de-Souza et al. Curr Microbiol. 2007 Feb.

Erratum in

  • Curr Microbiol. 2009 Sep;59(3):362. Martins, Daniel [corrected to Martins-de-Souza, Daniel]

Abstract

The fastidious bacterium Xylella fastidiosa is associated with important crop diseases worldwide. We have recently shown that X. fastidiosa is a peculiar organism having unusually low values of gene codon bias throughout its genome and, unexpectedly, in the group of the most abundant proteins. Here, we hypothesized that the lack of codon usage optimization in X. fastidiosa would incapacitate this organism to undergo quick and massive changes in protein expression as occurs in a classical stress response. Proteomic analysis of the response to heat stress in X. fastidiosa revealed that no changes in protein expression can be detected. Moreover, stress-inducible proteins identified in the closely related citrus pathogen Xanthomonas axonopodis pv citri were found to be constitutively expressed in X. fastidiosa. These proteins have extremely high codon bias values in the X. citri and other well-studied organisms, but low values in X. fastidiosa. Because biased codon usage is well known to correlate to the rate of protein synthesis, we speculate that the peculiar codon bias distribution in X. fastidiosa is related to the absence of a classical stress response, and, probably, alternative strategies for survival of X. fastidiosa under stressfull conditions.

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