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Review
. 2006 Winter;19(4):593-601.
doi: 10.1089/vim.2006.19.593.

Exploiting 4-1BB costimulation for enhancing antiviral vaccination

Jodie M Harrison  1 , Edward M Bertram, Ian A Ramshaw
Affiliations
Review

Exploiting 4-1BB costimulation for enhancing antiviral vaccination

Jodie M Harrison et al. Viral Immunol. 2006 Winter.

Abstract

4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8(+) T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8(+) T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in terms of boosting antiviral vaccine responses.

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