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. 2007 Feb;8(2):198-205.
doi: 10.1038/ni1426. Epub 2006 Dec 24.

The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens

Yen-Michael S Hsu  1 , Yongliang Zhang, Yun You, Donghai Wang, Hongxiu Li, Omar Duramad, Xiao-Feng Qin, Chen Dong, Xin Lin
Affiliations

The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens

Yen-Michael S Hsu et al. Nat Immunol. 2007 Feb.

Abstract

The caspase-recruitment domain-containing adaptor protein CARD9 regulates the innate signaling responses to fungal infection. Here we show that CARD9 is required for innate immune responses against intracellular pathogens. We generated Card9(-/-) mice and found that CARD9-deficient macrophages had defects in activation of the kinases p38 and Jnk but not of transcription factor NF-kappaB after bacterial and viral infection. CARD9-deficient mice failed to clear infection and showed altered cytokine production after challenge with Listeria monocytogenes. In wild-type cells, we found CARD9 inducibly associated with both the intracellular 'biosensor' Nod2 and the serine-threonine kinase RICK. Our data demonstrate that CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens.

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  • A pair of 9s: it's in the CARDs.
    Underhill DM, Shimada T. Underhill DM, et al. Nat Immunol. 2007 Feb;8(2):122-4. doi: 10.1038/ni0207-122. Nat Immunol. 2007. PMID: 17242682

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