doi: 10.1016/0968-0004(91)90088-d.
RNA recognition: towards identifying determinants of specificity
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- PMID: 1716386
- DOI: 10.1016/0968-0004(91)90088-d
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RNA recognition: towards identifying determinants of specificity
Trends Biochem Sci.
1991 Jun.
Abstract
Members of a family of proteins containing a conserved approximately 80-amino acid RNA recognition motif (RRM) bind specifically to a wide variety of RNA molecules. Structural studies, in combination with sequence alignments, indicate the structural context of both conserved and non-conserved elements in the motif. These analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.
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