Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
- PMID: 17136045
- DOI: 10.1038/ni1428
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
Abstract
Mice lacking the transcription factor Foxp3 (Foxp3(-)) lack regulatory T (T(reg)) cells and develop fatal autoimmune pathology. In Foxp3(-) mice, many activated effector T cells express self-reactive T cell receptors that are expressed in T(reg) cells in wild-type mice. Thus, in wild-type mice, most self-reactive thymocytes escaping negative selection are diverted into the T(reg) lineage, and whether T(reg) cells are critical in self-tolerance in wild-type mice remains unknown. Here, acute in vivo ablation of T(reg) cells demonstrated a vital function for T(reg) cells in neonatal and adult mice. We suggest that self-reactive T cells are continuously suppressed by T(reg) cells and that when suppression is relieved, self-reactive T cells become activated and facilitate accelerated maturation of dendritic cells.
Comment in
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Treg cells: guardians for life.Nat Immunol. 2007 Feb;8(2):124-5. doi: 10.1038/ni0207-124. Nat Immunol. 2007. PMID: 17242683
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