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Review
. 2006 Nov;25(5):691-3.
doi: 10.1016/j.immuni.2006.10.006.

BACing up the interferon-gamma locus

Christopher B Wilson  1 , Jamie Schoenborn
Affiliations
Review

BACing up the interferon-gamma locus

Christopher B Wilson et al. Immunity. 2006 Nov.

Abstract

In this issue of Immunity, Hatton et al. (2006) identify evolutionarily conserved noncoding sequences (CNSs) upstream of the interferon-gamma gene, then show by using a BAC transgene reporter that CNS-22 is a key regulator of interferon-gamma expression.

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Figures

Figure 1
Figure 1
Function of upstream conserved non-coding sequences (CNSs) and hypothetical architecture of the murine Ifng locus. (a) As shown by Hatton et al (2006), T-bet (yellow ovals) binds to each of the upstream CNSs, and CNS-34 and CNS-22 enhance Ifng-driven luciferase expression in the presence of T-bet (degree of enhancement indicated by + marks). CNS-5 and CNS+17 are shown as +?, since they did not enhance expression in this study, but in two previous studies enhanced Ifng expression in vitro and bound T-bet in vivo (Lee et al 2005, Shnyreva et al 2005). Previously defined DNase hypersensitive sites are denoted by downward arrows. (b) Top, constitutive approximation of CNS-5 (dark green region on gray chromosome 10) to the Ifng promoter (blue arrow) by intrachrosomal looping and interchromosomal interactions between the Ifng promoter and the Th2 locus (red region on black chromosome 11) in naïve and Th1 CD4 T cells, as shown by Spilianakis et al (2005). Bottom, hypothetical interactions based on Hatton et al (2006). Like CNS-5, CNS-22 (pink region) is hypothesized to be approximated to the Ifng promoter and with the Th2 cytokine locus in naïve CD4 T cells, whereas CNS-34 (light green region) and CNS+17 (dark blue region) are only recruited into the chromatin hub in IFN-γ producing Th1 cells.
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