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Review
. 2006 Oct;11(3-4):283-97.
doi: 10.1007/s10911-006-9024-2.

Pubertal mammary gland development: insights from mouse models

Jillian Howlin  1 , Jean McBryan, Finian Martin
Affiliations
Review

Pubertal mammary gland development: insights from mouse models

Jillian Howlin et al. J Mammary Gland Biol Neoplasia. 2006 Oct.

Abstract

During puberty the mammary gland develops from a rudimentary tree to a branched epithelial network of ducts which can support alveolar development and subsequent milk production during pregnancy and lactation. This process involves growth, proliferation, migration, branching, invasion, apoptosis and above all, tight regulation which allows these processes to take place simultaneously during the course of just a few weeks to create an adult gland. The process is under hormonal control and is thus coordinated with reproductive development. Mouse models, with overexpressed or knocked-out genes, have highlighted a number of pubertal mammary gland phenotypes and given significant insight into the regulatory mechanisms controlling this period of development. Here we review the published findings of the wide range of gene-manipulated mammary mouse models, documenting the common pubertal mammary gland phenotypes observed, and summarizing their contribution to our current understanding of how pubertal mammary gland development occurs.

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References

    1. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2196-201 - PubMed
    1. Endocrinology. 1990 Jun;126(6):3274-6 - PubMed
    1. Development. 2002 Jan;129(1):53-60 - PubMed
    1. J Mammary Gland Biol Neoplasia. 2002 Jan;7(1):17-38 - PubMed
    1. Oncogene. 2000 Feb 21;19(8):1102-13 - PubMed

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