Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism
- PMID: 17086187
- DOI: 10.1038/ni1406
Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism
Abstract
Fever is an evolutionarily conserved response during acute inflammation, although its physiological benefit is poorly understood. Here we show thermal stress in the range of fever temperatures increased the intravascular display of two 'gatekeeper' homing molecules, intercellular adhesion molecule 1 (ICAM-1) and CCL21 chemokine, exclusively in high endothelial venules (HEVs) that are chief portals for the entry of blood-borne lymphocytes into lymphoid organs. Enhanced endothelial expression of ICAM-1 and CCL21 was linked to increased lymphocyte trafficking across HEVs. A bifurcation in the mechanisms controlling HEV adhesion was demonstrated by evidence that the thermal induction of ICAM-1 but not of CCL21 involved an interleukin 6 trans-signaling pathway. Our findings identify the 'HEV axis' as a thermally sensitive alert system that heightens immune surveillance during inflammation by amplifying lymphocyte trafficking to lymphoid organs.
Comment in
-
Turning up the heat on HEVs.Nat Immunol. 2006 Dec;7(12):1288-90. doi: 10.1038/ni1206-1288. Nat Immunol. 2006. PMID: 17110949 No abstract available.
Similar articles
-
Targeted regulation of a lymphocyte-endothelial-interleukin-6 axis by thermal stress.Int J Hyperthermia. 2008 Feb;24(1):67-78. doi: 10.1080/02656730701772498. Int J Hyperthermia. 2008. PMID: 18214770 Review.
-
Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance.Cytokine. 2007 Jul;39(1):84-96. doi: 10.1016/j.cyto.2007.07.184. Cytokine. 2007. PMID: 17903700 Free PMC article. Review.
-
Thermal facilitation of lymphocyte trafficking involves temporal induction of intravascular ICAM-1.Microcirculation. 2009 Feb;16(2):143-158. doi: 10.1080/10739680802353850. Epub 2008 Dec 27. Microcirculation. 2009. PMID: 19031292 Free PMC article.
-
Turning up the heat on HEVs.Nat Immunol. 2006 Dec;7(12):1288-90. doi: 10.1038/ni1206-1288. Nat Immunol. 2006. PMID: 17110949 No abstract available.
-
Dynamic control of lymphocyte trafficking by fever-range thermal stress.Cancer Immunol Immunother. 2006 Mar;55(3):299-311. doi: 10.1007/s00262-005-0022-9. Epub 2005 Jul 26. Cancer Immunol Immunother. 2006. PMID: 16044255 Free PMC article. Review.
Cited by
-
Fine-tuning immune surveillance by fever-range thermal stress.Immunol Res. 2010 Mar;46(1-3):177-88. doi: 10.1007/s12026-009-8122-9. Immunol Res. 2010. PMID: 19760057 Free PMC article. Review.
-
Locoregional therapies and their effects on the tumoral microenvironment of pancreatic ductal adenocarcinoma.World J Gastroenterol. 2022 Apr 7;28(13):1288-1303. doi: 10.3748/wjg.v28.i13.1288. World J Gastroenterol. 2022. PMID: 35645539 Free PMC article. Review.
-
NK cells: immune cross-talk and therapeutic implications.Immunotherapy. 2011 Oct;3(10):1143-66. doi: 10.2217/imt.11.102. Immunotherapy. 2011. PMID: 21995569 Free PMC article. Review.
-
Hyperthermia as an immunotherapy strategy for cancer.Curr Opin Investig Drugs. 2009 Jun;10(6):550-8. Curr Opin Investig Drugs. 2009. PMID: 19513944 Free PMC article. Review.
-
Curcumin-galactomannoside complex inhibits pathogenesis in Ox-LDL-challenged human peripheral blood mononuclear cells.Inflammopharmacology. 2018 Oct;26(5):1273-1282. doi: 10.1007/s10787-018-0474-0. Epub 2018 Apr 9. Inflammopharmacology. 2018. PMID: 29633105
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Miscellaneous
