Review
doi: 10.1038/350569a0.
Structure and function of telomeres
- PMID: 1708110
- DOI: 10.1038/350569a0
Item in Clipboard
Review
Structure and function of telomeres
Nature.
.
Abstract
The DNA of telomeres--the terminal DNA-protein complexes of chromosomes--differs notably from other DNA sequences in both structure and function. Recent work has highlighted its remarkable mode of synthesis by the ribonucleoprotein reverse transcriptase, telomerase, as well as its ability to form unusual structures in vitro. Moreover, telomere synthesis by telomerase has been shown to be essential for telomere maintenance and long-term viability.
Similar articles
-
Telomeres, telomerase and senescence.Bioessays. 1990 Aug;12(8):363-9. doi: 10.1002/bies.950120803. Bioessays. 1990. PMID: 2241933 Review.
-
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.Nature. 1989 Jan 26;337(6205):331-7. doi: 10.1038/337331a0. Nature. 1989. PMID: 2463488
-
Developmentally programmed healing of chromosomes by telomerase in Tetrahymena.Cell. 1991 Nov 15;67(4):823-32. doi: 10.1016/0092-8674(91)90077-c. Cell. 1991. PMID: 1934071
-
Telomeres.Curr Opin Cell Biol. 1991 Jun;3(3):444-51. doi: 10.1016/0955-0674(91)90072-7. Curr Opin Cell Biol. 1991. PMID: 1892656 Review.
-
Telomeres.Trends Biochem Sci. 1991 Oct;16(10):378-81. doi: 10.1016/0968-0004(91)90155-o. Trends Biochem Sci. 1991. PMID: 1785140 Review.
Cited by
-
Sperm and leukocyte telomere length are related to sperm quality parameters in healthy men from the Led-Fertyl study.Hum Reprod Open. 2024 Oct 14;2024(4):hoae062. doi: 10.1093/hropen/hoae062. eCollection 2024. Hum Reprod Open. 2024. PMID: 39474122 Free PMC article.
-
Forging a signature of in vivo senescence.Nat Rev Cancer. 2015 Jul;15(7):397-408. doi: 10.1038/nrc3960. Nat Rev Cancer. 2015. PMID: 26105537 Review.
-
Habitat restoration weakens negative environmental effects on telomere dynamics.Mol Ecol. 2022 Dec;31(23):6100-6113. doi: 10.1111/mec.15980. Epub 2021 Jul 22. Mol Ecol. 2022. PMID: 33973299 Free PMC article.
-
The relationship between telomere length and beekeeping among Malaysians.Age (Dordr). 2015 Jun;37(3):9797. doi: 10.1007/s11357-015-9797-6. Epub 2015 Jun 2. Age (Dordr). 2015. PMID: 26028466 Free PMC article.
-
Telomere length reflects phenotypic quality and costs of reproduction in a long-lived seabird.Proc Biol Sci. 2012 Dec 5;280(1752):20122540. doi: 10.1098/rspb.2012.2540. Print 2013 Feb 7. Proc Biol Sci. 2012. PMID: 23222450 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
