Transcription factor TFIIIB and transcription by RNA polymerase III
- PMID: 17073756
- DOI: 10.1042/BST0341082
Transcription factor TFIIIB and transcription by RNA polymerase III
Abstract
pol (RNA polymerase) III is charged with the task of transcribing nuclear genes encoding diverse small structural and catalytic RNAs. We present a brief review of the current understanding of several aspects of the pol III transcription apparatus. The focus is on yeast and, more specifically, on Saccharomyces cerevisiae; preponderant attention is given to the TFs (transcription initiation factors) and especially to TFIIIB, which is the core pol III initiation factor by virtue of its role in recruiting pol III to the transcriptional start site and its essential roles in forming the transcription-ready open promoter complex. Certain relatively recent developments are also selected for brief comment: (i) the genome-wide analysis of occupancy of pol III-transcribed genes (and other loci) by the transcription apparatus and the location of pol III transcription in the cell; (ii) progress toward a mechanistic and molecular understanding of the regulation of transcription by pol III in yeast; and (iii) recent experiments identifying a high mobility group protein as a fidelity factor that assures selection of the precise transcriptional start site at certain pol III promoters.
Similar articles
-
Distinct roles of transcription factors TFIIIB and TFIIIC in RNA polymerase III transcription reinitiation.Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13442-7. doi: 10.1073/pnas.0403851101. Epub 2004 Sep 3. Proc Natl Acad Sci U S A. 2004. PMID: 15347814 Free PMC article.
-
p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB.EMBO J. 2003 Jun 2;22(11):2810-20. doi: 10.1093/emboj/cdg265. EMBO J. 2003. PMID: 12773395 Free PMC article.
-
hTFIIIB-beta stably binds to pol II promoters and recruits RNA polymerase III in a hTFIIIC1 dependent way.J Mol Biol. 1998 Nov 20;284(1):7-20. doi: 10.1006/jmbi.1998.2165. J Mol Biol. 1998. PMID: 9811538
-
Regulation of tRNA synthesis by the general transcription factors of RNA polymerase III - TFIIIB and TFIIIC, and by the MAF1 protein.Biochim Biophys Acta Gene Regul Mech. 2018 Apr;1861(4):320-329. doi: 10.1016/j.bbagrm.2018.01.011. Epub 2018 Feb 6. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 29378333 Review.
-
Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human.Nucleic Acids Res. 2001 Jul 1;29(13):2675-90. doi: 10.1093/nar/29.13.2675. Nucleic Acids Res. 2001. PMID: 11433012 Free PMC article. Review.
Cited by
-
Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.Nat Commun. 2017 Jul 25;8(1):130. doi: 10.1038/s41467-017-00126-1. Nat Commun. 2017. PMID: 28743884 Free PMC article.
-
Regulation of pol III transcription by nutrient and stress signaling pathways.Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):361-75. doi: 10.1016/j.bbagrm.2012.11.001. Epub 2012 Nov 16. Biochim Biophys Acta. 2013. PMID: 23165150 Free PMC article. Review.
-
TFIIB/SUA7(E202G) is an allele-specific suppressor of TBP1(E186D).Biochem J. 2007 Sep 1;406(2):265-71. doi: 10.1042/BJ20070441. Biochem J. 2007. PMID: 17680779 Free PMC article.
-
Local features determine Ty3 targeting frequency at RNA polymerase III transcription start sites.Genome Res. 2019 Aug;29(8):1298-1309. doi: 10.1101/gr.240861.118. Epub 2019 Jun 27. Genome Res. 2019. PMID: 31249062 Free PMC article.
-
A unique nucleosome arrangement, maintained actively by chromatin remodelers facilitates transcription of yeast tRNA genes.BMC Genomics. 2013 Jun 17;14:402. doi: 10.1186/1471-2164-14-402. BMC Genomics. 2013. PMID: 23767421 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
