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. 1975 Oct;16(4):844-53.
doi: 10.1128/JVI.16.4.844-853.1975.

Murine xenotropic type C viruses I. Distribution and further characterization of the virus in NZB mice

J A Levy, P Kazan, O Varnier, H Kleiman

Murine xenotropic type C viruses I. Distribution and further characterization of the virus in NZB mice

J A Levy et al. J Virol. 1975 Oct.

Abstract

The xenotropic mouse type C virus, originally detected in cultured embryo cells from New Zealand Black (NZB) mice, has been recovered from over 50 adult NZB animals and 15 NZB embryos. Its presence is best detected by measuring its ability to rescue a murine sarcoma virus (MSV) genome from a non-virus-producing MSV-transformed rat cell. The virus can serve as a helper for replication of MSV. It has a distinct type-specific coat and is a prototype for a third serotype of mouse type C viruses, NZB. The xenotropic virus may have an evolutionary role since it has a wide host range, including the ability to infect avian cells. It is produced spontaneously by all cells cultivated from NZB tissues and accounts for the high concentration of viral antigens associated with NZB tissues. The extent of virus production is similar in both male and female mice. All cell clones established from embryos also produce the virus. A variability in the intracellular regulation of virus replication is suggested since tissue cells from the same animal differ quantitatively in their ability to produce xenotropic viruses. Since enhanced spontaneous virus production is associated with cells from NZB mice, the virus may play a role in the autoimmune disease of this mouse strain.

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References

    1. J Bacteriol. 1966 Oct;92(4):1133-40 - PubMed
    1. J Cell Physiol. 1968 Oct;72(2):141-8 - PubMed
    1. Br J Haematol. 1963 Apr;9:119-31 - PubMed
    1. Ann Intern Med. 1963 Sep;59:265-76 - PubMed
    1. J Pathol Bacteriol. 1964 Jul;88:229-41 - PubMed

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