Review
. 2006 Nov;65 Suppl 3(Suppl 3):iii37-40.
doi: 10.1136/ard.2006.058446.
Role of nitric oxide in the regulation of T cell functions
Affiliations
- PMID: 17038470
- PMCID: PMC1798386
- DOI: 10.1136/ard.2006.058446
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Review
Role of nitric oxide in the regulation of T cell functions
Ann Rheum Dis.
2006 Nov.
Abstract
There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proliferation and the potential effect of nitric oxide on regulatory T (Treg) cells. On the basis of the results the authors propose that nitric oxide represents an additional signal for the induction of T cell subset response, contributing to the increasingly complex network of immune regulation essential for health and disease.
Conflict of interest statement
Competing interests: none declared
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