Review
doi: 10.1016/j.ijrobp.2006.06.034.
ReVOLT: radiation-enhanced viral oncolytic therapy
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- PMID: 17011442
- DOI: 10.1016/j.ijrobp.2006.06.034
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Review
ReVOLT: radiation-enhanced viral oncolytic therapy
Int J Radiat Oncol Biol Phys.
.
Abstract
Viral oncolytic therapy has been pursued with renewed interest as the molecular basis of carcinogenesis and viral replication has been elucidated. Genetically engineered, attenuated viruses have been rationally constructed to achieve a therapeutic index in tumor cells compared with surrounding normal tissue. Many of these attenuated mutant viruses have entered clinical trials. Here we review the preclinical literature demonstrating the interaction of oncolytic viruses with ionizing radiation and provides a basis for future clinical trials.
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