doi: 10.1081/COPD-120030412.
N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema
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- PMID: 16997736
- DOI: 10.1081/COPD-120030412
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N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema
COPD.
2004 Apr.
Free article
Abstract
Administration of the VEGF receptor blocker SU5416 to rats causes alveolar septal cell apoptosis and emphysema; both can be prevented by a superoxide dismutase mimetic. Here we show that SU5416 induces the expression of heme oxygenase-1 in the lung tissue and that administration of antioxidant N-acetyl-l-cysteine protects alveolar septal cells against apoptosis, as demonstrated by caspase-3 lung immunohistochemistry, and against emphysema.
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